ZFIN ID: ZDB-GENE-000831-6
Gene Name: Pim-2 proto-oncogene, serine/threonine kinase
Gene Symbol: pim2    Nomenclature History

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Previous Names: pim1 (1), cb1068 (1), fj47b05, wu:fj47b05

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in negative regulation of apoptotic process; protein autophosphorylation; and regulation of mitotic cell cycle. Predicted to localize to the cytoplasm. Is expressed in hatching gland; notochord; periderm; polster; and yolk syncytial layer. Orthologous to human PIM2 (Pim-2 proto-oncogene, serine/threonine kinase).
Genome Resources: Alliance (1),  Gene:58054 (1),  Ensembl(GRCz11):ENSDARG00000059001 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Directly Submitted Expression Data: 5 figures (7 images) from Thisse et al., 2001 [cb1068]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011754Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9268 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12616 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pim2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH pim2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hemopoiesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Family IPR017348 Serine/threonine-protein kinase pim-1/2/3
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pim2-201 (1)    Ensembl 2486
    ncRNA pim2-002 (1)    Ensembl 646
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pim2 No data available
    MARKER RELATIONSHIPS
    pim2 Contained in: [BAC] DKEY-83K24 (1) (order this), RP71-30I22 (1)
    pim2 Encodes: [EST] cb1068 (1) (order this), fj47b05 (1)
    [cDNA] MGC:55203 (1), MGC:86564 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131539 (1) 2460 nt
    Genomic GenBank:CR450685 (1) 195473 nt
    Select Tool
    Polypeptide UniProtKB:Q9YHZ5 (1) 310 aa
    Sequence Information (all 20)
    ORTHOLOGY for pim2 ( Chr: 8 )
    CITATIONS (28)