ZFIN ID: ZDB-GENE-000831-1
Gene Name: pyruvate carboxylase b
Gene Symbol: pcxb    Nomenclature History

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Previous Names: pc, pyc (1), PYCb (1), wu:fb82g08, wu:fj85g01 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have pyruvate carboxylase activity. Involved in response to cadmium ion. Predicted to localize to cytoplasm. Is expressed in brain; gill; liver; and musculature system. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase).
Genome Resources: Alliance (1),  Gene:58068 (1),  Ensembl(GRCz11):ENSDARG00000051939 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 4 publications
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026197Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12351 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21111 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34211 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pcxb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pcxb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pyruvate carboxylase deficiency disease Alliance Pyruvate carboxylase deficiency 266150
    DISEASE ASSOCIATED WITH pcxb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to cadmium ion (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pcxb-202 (1)    Ensembl 1828
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pcxb No data available
    MARKER RELATIONSHIPS
    pcxb Contained in: [BAC] CH211-194C5 (1), DKEY-46D17 (1) (order this), DKEYP-52E12 (1)
    pcxb Contains: [SNP] rs3728105 (1), rs3728106 (1), rs3728107 (1), rs3728108 (1), rs3728109 (1), rs3728110 (1), rs3728111 (1), rs3728112 (1)
    pcxb Encodes: [EST] fb82g08, fj85g01
    [cDNA] MGC:193840 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131550 (1) 4000 nt
    Genomic GenBank:AL772193 192531 nt
    Select Tool
    Polypeptide UniProtKB:B3DGZ9 (1) 1181 aa
    Sequence Information (all 53)
    ORTHOLOGY for pcxb ( Chr: 7 )
    CITATIONS (45)