ZFIN ID: ZDB-GENE-000713-1
Gene Name: caspase 8, apoptosis-related cysteine peptidase
Gene Symbol: casp8    Nomenclature History

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Previous Names: caspase-8a (1), zgc:92075

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Involved in induction by virus of host apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to cytoplasm. Is expressed in several structures, including axis; germ ring; heart; intestinal bulb; and nervous system. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; hepatocellular carcinoma; pancreatic cancer; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8).
Genome Resources: Alliance (1),  Gene:58022 (1),  Ensembl(GRCz11):ENSDARG00000058325 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-casp8 N/A 5
PHENOTYPE No data available
DISEASE ASSOCIATED WITH casp8 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 2B Alliance ?Autoimmune lymphoproliferative syndrome, type IIB 607271
breast cancer Alliance {Breast cancer, protection against} 114480
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
lung cancer Alliance {Lung cancer, protection against} 211980
DISEASE ASSOCIATED WITH casp8 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of apoptotic process (more)
Cellular Component cytoplasm (more)
Molecular Function cysteine-type endopeptidase activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA casp8-201 (1)    Ensembl 2027
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-casp8 polyclonal Rabbit IHC AnaSpec
3
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM casp8
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(ca8:FMA-TagRFP-2A-casp8-ERT2) ca8 2Acasp8ERT2FMATagRFP Danio rerio 1 2
Tg(ela3l:casp8,ela3l:Crimson) ela3l casp8Crimson Danio rerio 1 2
Tg(ins:casp8,ins:Crimson) ins casp8Crimson Danio rerio 1 2
MARKER RELATIONSHIPS
casp8 Contained in: [BAC] CH73-71C20 (1)
casp8 Encodes: [cDNA] MGC:92075 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131510 (1) 2056 nt
Genomic GenBank:CU639421 (1) 105459 nt
Select Tool
Polypeptide UniProtKB:A0A2U9DQK9 (1) 477 aa
Sequence Information (all 23)
ORTHOLOGY for casp8 ( Chr: 6 )
CITATIONS (106)