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General Information
ZIRC
ZFIN ID: ZDB-GENE-000713-1
Gene Name: caspase 8, apoptosis-related cysteine peptidase
Gene Symbol: casp8
Sequence Ontology ID : SO:0001217

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Attributions

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Previous Names: caspase-8a (1), zgc:92075

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway. Involved in induction by virus of host apoptotic process and regulation of cysteine-type endopeptidase  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents:
PHENOTYPE No data available
DISEASE ASSOCIATED WITH casp8 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 2B ?Autoimmune lymphoproliferative syndrome, type IIB 607271
breast cancer {Breast cancer, protection against} 114480
hepatocellular carcinoma Hepatocellular carcinoma, somatic 114550
lung cancer {Lung cancer, protection against} 211980
DISEASE ASSOCIATED WITH casp8 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process positive regulation of apoptotic process (more)
Cellular Component cytoplasm (more)
Molecular Function cysteine-type endopeptidase activity (more)
GO Terms (all 12)
TRANSCRIPTS
Type Name Length (bp) Analysis
mRNA casp8-201 (1) 2027
GENE PRODUCT DESCRIPTION
INTERACTIONS AND PATHWAYS
ANTIBODIES
PLASMIDS No data available
MARKER RELATIONSHIPS
casp8 Contained in: [BAC] CH73-71C20 (1) (order this)
casp8 Encodes: [cDNA] MGC:92075 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131510 (1) 2056 bp
Genomic GenBank:CU639421 (1) 105459 bp
Select Tool
Polypeptide UniProtKB:A0A2U9DQK9 (1) 477 aa
Sequence Clusters UniGene:10334 (1)
Sequence Information (all 24)
ORTHOLOGY for casp8 ( Chr: 6 )
CITATIONS (95)