Gene
casp8
- ID
- ZDB-GENE-000713-1
- Name
- caspase 8, apoptosis-related cysteine peptidase
- Symbol
- casp8 Nomenclature History
- Previous Names
-
- caspase-8a (1)
- zgc:92075
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and death effector domain binding activity. Involved in induction by virus of host apoptotic process and regulation of cysteine-type endopeptidase activity involved in apoptotic process. Predicted to localize to cytoplasm. Is expressed in several structures, including axis; germ ring; heart; intestinal bulb; and nervous system. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; hepatocellular carcinoma; pancreatic cancer; and primary immunodeficiency disease. Orthologous to human CASP8 (caspase 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 44 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autoimmune lymphoproliferative syndrome type 2B | Alliance | ?Caspase 8 lymphadenopathy syndrome | 607271 |
| breast cancer | Alliance | {Breast cancer, protection against} | 114480 |
| hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
| lung cancer | Alliance | {Lung cancer, protection against} | 211980 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR033139 | Peptidase family C14A, cysteine active site |
| Domain | IPR001309 | Peptidase C14, p20 domain |
| Domain | IPR001875 | Death effector domain |
| Domain | IPR002138 | Peptidase C14, caspase non-catalytic subunit p10 |
| Domain | IPR011600 | Peptidase C14, caspase domain |
| Domain | IPR015917 | Peptidase C14A, caspase catalytic domain |
| Family | IPR051290 | CASP8 and FADD-like apoptosis regulator |
| Homologous_superfamily | IPR011029 | Death-like domain superfamily |
| Homologous_superfamily | IPR029030 | Caspase-like domain superfamily |
Domain Details Per Protein
| Protein | Length | CASP8 and FADD-like apoptosis regulator | Caspase-like domain superfamily | Death effector domain | Death-like domain superfamily | Peptidase C14A, caspase catalytic domain | Peptidase C14, caspase domain | Peptidase C14, caspase non-catalytic subunit p10 | Peptidase C14, p20 domain | Peptidase family C14A, cysteine active site |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BD46
|
477 | |||||||||
|
UniProtKB:Q66I19
|
476 |
Interactions and Pathways
No data available
Plasmids
No data available