Gene
tnnt2a
- ID
- ZDB-GENE-000626-1
- Name
- troponin T type 2a (cardiac)
- Symbol
- tnnt2a Nomenclature History
- Previous Names
-
- ctnnt (1)
- cTnT
- tnnt2
- sih
- silent heart
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have cytoskeletal protein binding activity and protein-macromolecule adaptor activity. Involved in several processes, including animal organ development; circulatory system development; and nitric oxide biosynthetic process. Localizes to troponin complex. Is expressed in cardiac muscle; cardiovascular system; and mesoderm. Used to study hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type).
- Genome Resources
- Note
- None
- All Expression Data
- 24 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 87 figures from 59 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
dilated cardiomyopathy 1D | Alliance | Cardiomyopathy, dilated, 1D | 601494 |
dilated cardiomyopathy 1D | Alliance | Left ventricular noncompaction 6 | 601494 |
hypertrophic cardiomyopathy 2 | Alliance | Cardiomyopathy, hypertrophic, 2 | 115195 |
restrictive cardiomyopathy 3 | Alliance | Cardiomyopathy, familial restrictive, 3 | 612422 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
cardiomyopathy | tnnt2afdu108/fdu108 | standard conditions | Liu et al., 2019 |
hypertrophic cardiomyopathy | bw6Tg + MO3-tnnt2a | control | Becker et al., 2012 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Troponin | Troponin domain superfamily | Troponin T |
---|---|---|---|---|
UniProtKB:Q7ZSY4
|
282 | |||
UniProtKB:Q804V7
|
264 | |||
UniProtKB:Q8JFS9
|
272 | |||
UniProtKB:F8W403
|
221 | |||
UniProtKB:A8E586
|
282 | |||
UniProtKB:E7EYC9
|
282 | |||
UniProtKB:Q90Y46
|
282 | |||
UniProtKB:Q8AW31
|
271 | |||
UniProtKB:F1R0K6
|
264 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA | tnnt2a-001 (1) | 866 nt | |
mRNA |
tnnt2a-203
(1)
|
693 nt | |
mRNA |
tnnt2a-204
(1)
|
1176 nt |
Interactions and Pathways
No data available
Plasmids
No data available