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ZIRC
ZFIN ID: ZDB-GENE-000626-1
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Gene Name: troponin T type 2a (cardiac)
Gene Symbol: tnnt2a
Sequence Ontology ID : SO:0000704

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Previous Names: cTnT, tnnt2, sih, silent heart

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(Including Attributions)
Location: Chr: 23 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to contribute to calcium-dependent ATPase activity and tropomyosin binding activity. Involved in several processes, including animal organ development; circulatory system development; and  ...
GENE EXPRESSION
All Expression Data: 19 figures from 13 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2005 [eu662]
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b109 Small Deletion Unknown Unknown G_RAYS
hu5753 Unknown Unknown Unknown
mn0031Gt Transgenic Insertion Unknown Unknown DNA
sa24250 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa32424 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • tc300b Point Mutation Acceptor Splice Site of Exon 3 Splice Site, Frameshift, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • tnnt2a_unspecified Unspecified Unknown Unknown
    Targeting reagents:
    PHENOTYPE
    Data: 78 figures from 54 publications
    Observed in:
    DISEASE ASSOCIATED WITH tnnt2a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1D Cardiomyopathy, dilated, 1D 601494
    Left ventricular noncompaction 6 601494
    hypertrophic cardiomyopathy 2 Cardiomyopathy, hypertrophic, 2 115195
    restrictive cardiomyopathy Cardiomyopathy, familial restrictive, 3 612422
    DISEASE ASSOCIATED WITH tnnt2a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    hypertrophic cardiomyopathy bw6Tg + MO3-tnnt2a control Becker et al., 2012
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of nitric oxide mediated signal transduction (more)
    Cellular Component troponin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 34)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001978 (1)
  • InterPro:IPR027707 (1)
  • InterPro:IPR038077 (1)
    		•
  • Pfam:PF00992 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tnnt2a-001 (1) 866
    Select Tool
    tnnt2a-203 (1) 693
    Select Tool
    tnnt2a-204 (1) 1176
    Select Tool
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tnnt2a
    MARKER RELATIONSHIPS
    tnnt2aContained in: [BAC] CH73-187I15 (1) (order this)
    [PAC] BUSM1-65I4 (1) (order this), BUSM1-182N13 (1) (order this)
    tnnt2aContains: [SNP] rs3729228 (1), rs3729229 (1), rs3729230 (1), rs3729231 (1), rs3729232 (1)
    tnnt2aEncodes: [EST] eu662 (1), zeh0954
    [cDNA] MGC:123151 (1) (order this), MGC:171408 (1) (order this), MGC:174148 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152893 (1) 1047bp
    Select Tool
    Genomic GenBank:AL662880 (1) 103409bp
    Select Tool
    Polypeptide UniProtKB:A8E586 (1) 282aa
    Select Tool
    Sequence Clusters UniGene:14260 (1)
    Sequence Information (all 42)
    OTHER tnnt2a GENE PAGES
  • Alliance (1)
  • Gene:58071 (1)
  • VEGA:OTTDARG00000003817 (1)
  • VEGA:OTTDARG00000034080 (1)
  • Ensembl(GRCz11):ENSDARG00000020610 (1)
    • ORTHOLOGY for tnnt2a (Chr: 23)
    CITATIONS (226)