Gene

tnnt2a

ID

ZDB-GENE-000626-1

Name

troponin T type 2a (cardiac)

Symbol

tnnt2a Nomenclature History

Previous Names

ctnnt (1)
cTnT
tnnt2
sih
silent heart

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to enable cytoskeletal protein binding activity and protein-macromolecule adaptor activity. Predicted to be a structural constituent of cytoskeleton. Acts upstream of or within several processes, including circulatory system development; hematopoietic stem cell differentiation; and nitric oxide biosynthetic process. Part of troponin complex. Is expressed in cardiac muscle; cardiovascular system; and mesoderm. Used to study cardiomyopathy and hypertrophic cardiomyopathy. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

29 figures from 21 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu662 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 97 figures from 62 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tnnt2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dilated cardiomyopathy 1D	Alliance	Cardiomyopathy, dilated, 1D	601494
dilated cardiomyopathy 1D	Alliance	Left ventricular noncompaction 6	601494
hypertrophic cardiomyopathy 2	Alliance	Cardiomyopathy, hypertrophic, 2	115195
restrictive cardiomyopathy 3	Alliance	Cardiomyopathy, familial restrictive, 3	612422

Associated With tnnt2a Via Experimental Models

Human Disease	Fish	Conditions	Citations
cardiomyopathy	tnnt2a^{fdu108/fdu108}	standard conditions	Liu et al., 2019
hypertrophic cardiomyopathy	bw6Tg + MO3-tnnt2a	control	Becker et al., 2012

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR001978	Troponin
Family	IPR027707	Troponin T
Homologous_superfamily	IPR038077	Troponin domain superfamily

Domain Details Per Protein

Protein	Length	Troponin	Troponin domain superfamily	Troponin T
UniProtKB:A8E586 InterPro	282
UniProtKB:E7EYC9 InterPro	282
UniProtKB:F1R0K6 InterPro	264
UniProtKB:Q804V7 InterPro	264
UniProtKB:Q90Y46 InterPro	282
UniProtKB:Q8JFS9 InterPro	272
UniProtKB:Q7ZSY4 InterPro	282
UniProtKB:Q8AW31 InterPro	271
UniProtKB:F8W403 InterPro	221

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tnnt2a-001 (1)	866 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tnnt2a-203 (1) Ensembl	693 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tnnt2a-204 (1) Ensembl	1176 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tnnt2	monoclonal	tnnt2a	IgG	Mouse	IHC	Developmental Studies Hybridoma Bank	3

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations