Gene

gata6

ID
ZDB-GENE-000622-1
Name
GATA binding protein 6
Symbol
gata6 Nomenclature History
Previous Names
  • GATA-5
  • cb603 (1)
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Enables DNA binding activity. Acts upstream of or within animal organ development; digestive tract development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; digestive system; endoderm; mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to human GATA6 (GATA binding protein 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
81 figures from 57 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gata6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
atrial heart septal defect 9 Alliance Atrial septal defect 9 614475
atrioventricular septal defect Alliance Atrioventricular septal defect 5 614474
double outlet right ventricle Alliance Persistent truncus arteriosus 217095
pancreatic hypoplasia-diabetes-congenital heart disease syndrome Alliance Pancreatic agenesis and congenital heart defects 600001
tetralogy of Fallot Alliance Tetralogy of Fallot 187500
Associated With gata6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000679 Zinc finger, GATA-type
Domain IPR008013 GATA-type transcription activator, N-terminal
Family IPR016375 Transcription factor GATA-4/5/6
Family IPR028437 Transcription factor GATA-6
Family IPR039355 Transcription factor GATA
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Domain Details Per Protein
Protein Length GATA-type transcription activator, N-terminal Transcription factor GATA Transcription factor GATA-4/5/6 Transcription factor GATA-6 Zinc finger, GATA-type Zinc finger, NHR/GATA-type
UniProtKB:Q9PTJ1 383
UniProtKB:Q6NW63 501
UniProtKB:A0A0R4IB15 401
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations