Gene

adar

ID
ZDB-GENE-000616-5
Name
adenosine deaminase RNA specific
Symbol
adar Nomenclature History
Previous Names
  • drada
  • red1
  • wu:fc22a02 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to localize to cytoplasm and nucleolus. Is expressed in brain. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and dyschromatosis symmetrica hereditaria. Orthologous to human ADAR (adenosine deaminase RNA specific).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With adar Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Aicardi-Goutieres syndrome Alliance Aicardi-Goutieres syndrome 6 615010
dyschromatosis symmetrica hereditaria Alliance Dyschromatosis symmetrica hereditaria 127400
Associated With adar Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002466 Adenosine deaminase/editase
Domain IPR014720 Double-stranded RNA-binding domain
Domain IPR042371 Z-alpha domain
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Repeat IPR000607 Double-stranded RNA-specific adenosine deaminase (DRADA) repeat
Domain Details Per Protein
Protein Length Adenosine deaminase/editase Double-stranded RNA-binding domain Double-stranded RNA-specific adenosine deaminase (DRADA) repeat Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily Z-alpha domain
UniProtKB:E9QIW2 1381
UniProtKB:Q803S9 917
UniProtKB:Q9I8Y2 1382
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations