ZFIN ID: ZDB-GENE-000616-5
Gene Name: adenosine deaminase RNA specific
Gene Symbol: adar    Nomenclature History

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Previous Names: drada, red1, wu:fc22a02 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have double-stranded RNA adenosine deaminase activity; double-stranded RNA binding activity; and tRNA-specific adenosine deaminase activity. Predicted to be involved in RNA processing and adenosine to inosine editing. Predicted to localize to cytoplasm and nucleolus. Is expressed in brain. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and dyschromatosis symmetrica hereditaria. Orthologous to human ADAR (adenosine deaminase RNA specific).
Genome Resources: Alliance (1),  Gene:58119 (1),  Ensembl(GRCz11):ENSDARG00000012389 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu29]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 6 (144.0h-168.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa817 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6428 Point Mutation Unknown Premature Stop ENU
    sa16847 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18476 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22832 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-adar N/A 1
    MO2-adar N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH adar HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Aicardi-Goutieres syndrome Alliance Aicardi-Goutieres syndrome 6 615010
    dyschromatosis symmetrica hereditaria Alliance Dyschromatosis symmetrica hereditaria 127400
    DISEASE ASSOCIATED WITH adar VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process RNA processing (more)
    Cellular Component cytoplasm (more)
    Molecular Function adenosine deaminase activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adar-201 (1)    Ensembl 5421
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adar No data available
    MARKER RELATIONSHIPS
    adar Contained in: [BAC] CH211-216F21 (1)
    adar Encodes: [EST] eu29 (1), fc22a02 (1)
    [cDNA] MGC:55234 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131596 (1) 5349 nt
    Genomic GenBank:CR533578 (1) 214872 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q9I8Y2 (1) 1382 aa
    Sequence Information (all 17)
    ORTHOLOGY for adar ( Chr: 16 )
    CITATIONS (32)