ZFIN ID: ZDB-GENE-000616-3
Gene Name: caspase a
Gene Symbol: caspa    Nomenclature History

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Previous Names: casp1 (1), caspy (1), fa93b02, wu:fa93b02 (1), zgc:109869

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits Pyrin domain binding activity and cysteine-type endopeptidase activity. Involved in embryonic viscerocranium morphogenesis; innate immune response; and positive regulation of apoptotic process. Predicted to localize to cytoplasm. Is expressed in integument; intestinal bulb; mouth; and pharyngeal arch. Orthologous to human CASP1 (caspase 1) and CASP4 (caspase 4).
Genome Resources: Alliance (1),  Gene:57933 (1),  Ensembl(GRCz11):ENSDARG00000008165 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 4 publications
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hdb11 Small Deletion Unknown Frameshift, Premature Stop CRISPR
hdb12 Insertion Exon 1 Premature Stop CRISPR
sa36229 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-caspa 1
    CRISPR1-pycard,caspa 1
    CRISPR2-caspa
    1
    CRISPR3-caspa
    1
    CRISPR4-caspa
    1
    MO1-caspa N/A 3
    MO2-caspa N/A 2
    DISEASE ASSOCIATED WITH caspa HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH caspa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of apoptotic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function cysteine-type endopeptidase activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA caspa-201 (1)    Ensembl 1542
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM caspa No data available
    MARKER RELATIONSHIPS
    caspa Contained in: [BAC] CH211-225P5 (1)
    caspa Encodes: [EST] fa93b02 (1)
    [cDNA] MGC:109869 (1), MGC:191955 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131505 (1) 1533 nt
    Genomic GenBank:BX649388 (1) 177865 nt
    Select Tool
    Polypeptide UniProtKB:Q9I9L7 (1) 383 aa
    Sequence Information (all 20)
    ORTHOLOGY for caspa ( Chr: 16 )
    CITATIONS (50)