Gene

hsf1

ID
ZDB-GENE-000616-16
Name
heat shock transcription factor 1
Symbol
hsf1 Nomenclature History
Previous Names
  • hsf1a
  • hsf1b
  • HSF1c (1)
  • zHSF1a
  • zHSF1b
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in lens development in camera-type eye and response to heat. Predicted to localize to nucleus. Is expressed in brain; head; and otic vesicle. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human HSF1 (heat shock transcription factor 1).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 6 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hsf1 Human Ortholog
No data available
Associated With hsf1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000232 Heat shock factor (HSF)-type, DNA-binding
Domain IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
Family IPR027725 Heat shock transcription factor family
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Heat shock factor (HSF)-type, DNA-binding Heat shock transcription factor family Vertebrate heat shock transcription factor, C-terminal domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q1LXV0 497
UniProtKB:Q90YY9 497
UniProtKB:Q9IAS1 512
UniProtKB:F6P697 523
UniProtKB:Q8UWM7 497
UniProtKB:Q9IAS0 538
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-hsf1 monoclonal IgG1 Rat
  • IHC
Thermo Fisher Scientific (Lab Vision)
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations