ZFIN ID: ZDB-GENE-000607-52
Gene Name: K(lysine) acetyltransferase 6B
Gene Symbol: kat6b    Nomenclature History

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Previous Names: id:ibd5103 (1), si:dkey-24f15.3 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have histone acetyltransferase activity and histone binding activity. Predicted to be involved in histone H3 acetylation; negative regulation of transcription, DNA-templated; and positive regulation of transcription by RNA polymerase II. Predicted to localize to MOZ/MORF histone acetyltransferase complex and nuclear chromatin. Is expressed in forebrain. Human ortholog(s) of this gene implicated in bipolar disorder; blepharophimosis-intellectual disability syndrome, SBBYS type; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B).
Genome Resources: Alliance (1),  Gene:568932 (1),  Ensembl(GRCz11):ENSDARG00000055429 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 2 figures (2 images) from Kudoh et al., 2001 [ibd5103]
Wild-type Stages, Structures: Segmentation:5-9 somites (11.66h-14.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1676 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14848 Point Mutation Unknown Premature Stop ENU
    sa15696 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16535 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42204 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-kat6b N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kat6b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    blepharophimosis-intellectual disability syndrome, SBBYS type Alliance SBBYSS syndrome 603736
    Genitopatellar syndrome 606170
    DISEASE ASSOCIATED WITH kat6b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process histone acetylation (more)
    Cellular Component host cell nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kat6b-202 (1)    Ensembl 4107
    kat6b-203 (1)    Ensembl 1938
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kat6b No data available
    MARKER RELATIONSHIPS
    kat6b Contained in: [BAC] DKEY-24F15 (1) (order this)
    kat6b Encodes: [EST] ibd5103
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009307391 (1)
    Genomic GenBank:AL929334 (1) 226833 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B7ZD46 (1) 1368 aa
    Sequence Information (all 28)
    ORTHOLOGY for kat6b ( Chr: 13 )
    CITATIONS (24)