header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-000526-1
Gene Name: hes-related family bHLH transcription factor with YRPW motif 2
Gene Symbol: hey2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: gridlock (1), grl (1), Herp2 (1), zgc:136746 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in circulatory system development and negative regulation of transcription, DNA-templated. Predicted to localize to the nucleus. Is expressed in several structures, including alar plate midbrain region; cardiovascular system; hematopoietic system; mesoderm; and nervous system. Orthologous to human HEY2 (hes related family bHLH transcription factor with YRPW motif 2).
Genome Resources: Alliance (1),  Gene:58146 (1),  Ensembl(GRCz11):ENSDARG00000013441 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hsc25 Small Deletion Unknown Unknown CRISPR
hsc27Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
m145 Point Mutation Unknown Missense ENU
sa10785 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16273 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23783 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29430 Point Mutation Unknown Premature Stop ENU
    vu59 Point Mutation Unknown Premature Stop ENU
    zf80 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hey2 1
    MO1-hey2 N/A 11
    MO2-hey2 N/A 1
    TALEN1-hey2
    2
    TALEN2-hey2
    1
    DISEASE ASSOCIATED WITH hey2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hey2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 23)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hey2-201 (1)    Ensembl 1816
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM hey2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg1(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-hey2-LOXP-gata2a:EGFP-5HS4) gata2ahey2 5HS4DsRedEGFPGAB Danio rerioXenopus laevis 3 3
    Tg2(FRT-Xla.Actc1:DsRed-GAB-FRT,LOXP-hey2-LOXP-gata2a:EGFP-5HS4) gata2ahey2 5HS4DsRedEGFPGAB Danio rerioXenopus laevis 3 3
    MARKER RELATIONSHIPS
    hey2 Contained in: [BAC] CH211-172B22 (1) (order this)
    hey2 Encodes: [EST] eu521 (1)
    [cDNA] MGC:136746 (1) (order this), MGC:194026 (1), MGC:194033 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131622 (1) 1898 bp
    Genomic GenBank:CT573083 (1) 40018 bp
    Select Tool
    Polypeptide UniProtKB:B3DGE6 (1) 324 aa
    Sequence Clusters UniGene:81319 (1)
    Sequence Information (all 23)
    ORTHOLOGY for hey2 ( Chr: 20 )
    CITATIONS (138)