Gene

mcl1a

ID
ZDB-GENE-000511-7
Name
MCL1 apoptosis regulator, BCL2 family member a
Symbol
mcl1a Nomenclature History
Previous Names
  • zfMcl-1a
  • fb70a08
  • fb72f02
  • wu:fb70a08
  • wu:fb72f02 (1)
  • zfMLP1 (1)
  • zgc:109835
Type
protein_coding_gene
Location
Chr: 19 Mapping Details/Browsers
Description
Exhibits protein heterodimerization activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of mitotic nuclear division; and tissue homeostasis. Predicted to localize to mitochondrial outer membrane. Is expressed in digestive system; eye; heart; and pleuroperitoneal region. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mcl1a Human Ortholog
No data available
Associated With mcl1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002475 Bcl2-like
Family IPR013281 Apoptosis regulator, Mcl-1
Family IPR026298 Blc2 family
Homologous_superfamily IPR036834 Blc2-like superfamily
Domain Details Per Protein
Protein Length Apoptosis regulator, Mcl-1 Bcl2-like Blc2 family Blc2-like superfamily
UniProtKB:Q9I9N3 255
UniProtKB:Q1L8X3 255
UniProtKB:Q568V1 243
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations