ZFIN ID: ZDB-GENE-000511-7
Gene Name: MCL1 apoptosis regulator, BCL2 family member a
Gene Symbol: mcl1a    Nomenclature History

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Previous Names: zfMcl-1a, fb70a08, fb72f02, wu:fb70a08, wu:fb72f02 (1), zfMLP1 (1), zgc:109835

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of mitotic nuclear division; and tissue homeostasis. Predicted to localize to the mitochondrial outer membrane. Is expressed in digestive system; eye; heart; and pleuroperitoneal region. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member).
Genome Resources: Alliance (1),  Gene:58122 (1),  Ensembl(GRCz11):ENSDARG00000009779 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:109835]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10132 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12089 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mcl1a N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mcl1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH mcl1a VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR002475 Bcl2-like
    Family IPR013281 Apoptosis regulator, Mcl-1
    Family IPR026298 Blc2 family
    Homologous_superfamily IPR036834 Blc2-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mcl1a-201 (1)    Ensembl 1409
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mcl1a No data available
    MARKER RELATIONSHIPS
    mcl1a Contained in: [BAC] DKEYP-24A7 (1)
    mcl1a Encodes: [EST] fb70a08, fb72f02 (1)
    [cDNA] MGC:109835 (1), MGC:192271 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131599 (1) 1253 bp
    Genomic GenBank:CR548627 (1) 146348 bp
    Select Tool
    Polypeptide UniProtKB:Q1L8X3 (1) 255 aa
    Sequence Clusters UniGene:33208 (1)
    Sequence Information (all 23)
    ORTHOLOGY for mcl1a ( Chr: 19 )
    CITATIONS (43)