ZFIN ID: ZDB-GENE-000412-1
Gene Name: brain-derived neurotrophic factor
Gene Symbol: bdnf    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have growth factor activity and nerve growth factor receptor binding activity. Involved in multicellular organismal response to stress and nervous system development. Predicted to localize to several cellular components, including axon; dendrite; and synaptic vesicle. Is expressed in several structures, including blastoderm; digestive system; nervous system; oral region; and pericardial region. Human ortholog(s) of this gene implicated in several diseases, including cognitive disorder (multiple); congenital central hypoventilation syndrome; neurodegenerative disease (multiple); obstructive sleep apnea; and status epilepticus. Orthologous to human BDNF (brain derived neurotrophic factor).
Genome Resources: Alliance (1),  Gene:58118 (1),  Ensembl(GRCz11):ENSDARG00000018817 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34104 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bdnf N/A 4
    MO2-bdnf N/A 1
    DISEASE ASSOCIATED WITH bdnf HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH bdnf VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process presynapse assembly (more)
    Cellular Component axon (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bdnf-201 (1)    Ensembl 1866
    bdnf-202 (1)    Ensembl 1100
    bdnf-203 (1)    Ensembl 1446
    bdnf-204 (1)    Ensembl 857
    bdnf-205 (1)    Ensembl 869
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-bdnf polyclonal Rabbit IHC, WB Millipore
    6
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM bdnf No data available
    MARKER RELATIONSHIPS
    bdnf Contained in: [BAC] CH73-387L4 (1), CH211-214A19 (1), CH211-251J8 (1)
    bdnf Encodes: [cDNA] MGC:65746 (1), MGC:76834 (1), MGC:76835 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131595 (1) 1904 nt
    Genomic GenBank:AL935207 (1) 146351 nt
    Select Tool
    Polypeptide UniProtKB:Q6NZ01 (1) 270 aa
    Sequence Information (all 33)
    ORTHOLOGY for bdnf ( Chr: 7 )
    CITATIONS (117)