ZFIN ID: ZDB-GENE-000406-8
Gene Name: mesoderm posterior aa
Gene Symbol: mespaa    Nomenclature History

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Previous Names: mesp-a, Mesp1 (1), mespa

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; gastrulation; and regionalization. Predicted to localize to nucleus. Is expressed in hypoblast; margin; paraxial mesoderm; presumptive paraxial mesoderm; and somite. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2).
Genome Resources: Alliance (1),  Gene:58069 (1),  Ensembl(GRCz11):ENSDARG00000017078 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hsc11 Small Deletion Unknown Premature Stop CRISPR
kt1017 Indel Unknown Unknown TALEN
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-mespaa 1
MO1-mespaa N/A 2
TALEN1-mespaa 1
DISEASE ASSOCIATED WITH mespaa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylocostal dysostosis Alliance Spondylocostal dysostosis 2, autosomal recessive 608681
DISEASE ASSOCIATED WITH mespaa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to retinoic acid (more)
Cellular Component nucleus (more)
Molecular Function DNA-binding transcription factor activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mespaa-201 (1)    Ensembl 887
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mespaa No data available
MARKER RELATIONSHIPS
mespaa Contained in: [BAC] CH211-276A23 (1)
mespaa Encodes: [cDNA] MGC:193584 (1), MGC:193614 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131551 (1) 887 nt
Genomic GenBank:CR848709 (1) 153072 nt
Select Tool
Polypeptide UniProtKB:B3DFN8 (1) 223 aa
Sequence Information (all 17)
ORTHOLOGY for mespaa ( Chr: 7 )
CITATIONS (63)