Gene

mespaa

ID
ZDB-GENE-000406-8
Name
mesoderm posterior aa
Symbol
mespaa Nomenclature History
Previous Names
  • mesp-a
  • Mesp1 (1)
  • mespa
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; gastrulation; and regionalization. Predicted to localize to nucleus. Is expressed in hypoblast; margin; paraxial mesoderm; presumptive paraxial mesoderm; and somite. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human MESP2 (mesoderm posterior bHLH transcription factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
47 figures from 30 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mespaa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylocostal dysostosis Alliance Spondylocostal dysostosis 2, autosomal recessive 608681
Associated With mespaa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Family IPR040259 Mesogenin/MesP
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Mesogenin/MesP Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:B3DFN8 223
UniProtKB:Q9IAJ4 223
UniProtKB:Q9IB70 223
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Note
Deleted orthology data derived from Woods et al. (ZDB-PUB-050823-6 ).
Citations