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ZIRC
ZFIN ID: ZDB-GENE-000403-1
Gene Name: axin 1
Gene Symbol: axin1    Nomenclature History

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Previous Names: masterblind, mbl, wu:fi22e03, wu:fj14c08, wu:fk11b03 (1), zgc:109872

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have protein homodimerization activity. Involved in several processes, including embryonic morphogenesis; negative regulation of Wnt signaling pathway; and regionalization. Localizes to the beta-catenin destruction complex. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is expressed in forebrain; habenula; and midbrain. Orthologous to human AXIN1 (axin 1).
Genome Resources: Alliance (1),  Gene:57931 (1),  Ensembl(GRCz11):ENSDARG00000102964 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Cleavage:8-cell (1.25h-1.5h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028927Tg Transgenic Insertion Unknown Unknown DNA
sa20109 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tm13 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm213 Point Mutation Unknown Missense
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-axin1 N/A 2
    MO2-axin1 N/A 2
    DISEASE ASSOCIATED WITH axin1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
    ?Caudal duplication anomaly 607864
    DISEASE ASSOCIATED WITH axin1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of JUN kinase activity (more)
    Cellular Component beta-catenin destruction complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 29)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA axin1-201 (1)    Ensembl 4734
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM axin1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:GFP-axin1) hsp70l axin1GFP Danio rerio 1 4
    MARKER RELATIONSHIPS
    axin1 Contained in: [BAC] CH73-54I21 (1) (order this), CH211-25B15 (1) (order this)
    axin1 Contains: [SNP] rs3727728 (1), rs3727729 (1)
    axin1 Encodes: [EST] fi22e03 (1), fj14c08 (1), fk11b03 (1)
    [cDNA] MGC:109872 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131503 (1) 4742 bp
    Genomic GenBank:CU138533 (1) 115648 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4II61 (1) 835 aa
    Sequence Clusters UniGene:80549 (1)
    Sequence Information (all 30)
    ORTHOLOGY for axin1 ( Chr: 3 )
    CITATIONS (105)