Gene

axin1

ID
ZDB-GENE-000403-1
Name
axin 1
Symbol
axin1 Nomenclature History
Previous Names
  • masterblind
  • mbl
  • wu:fi22e03
  • wu:fj14c08
  • wu:fk11b03 (1)
  • zgc:109872
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have protein homodimerization activity. Involved in several processes, including embryonic morphogenesis; negative regulation of Wnt signaling pathway; and regionalization. Localizes to beta-catenin destruction complex. Is expressed in forebrain; habenula; head; and midbrain. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human AXIN1 (axin 1).
Genome Resources
Note
None
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
28 figures from 16 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With axin1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
?Caudal duplication anomaly 607864
Associated With axin1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001158 DIX domain
Domain IPR014936 Axin beta-catenin binding
Domain IPR016137 RGS domain
Domain IPR032101 Axin-1/2, tankyrase-binding domain
Family IPR029797 Axin-1
Family IPR043581 Axin-like
Homologous_superfamily IPR024066 RGS, subdomain 1/3
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR036305 RGS domain superfamily
Homologous_superfamily IPR038207 DIX domain superfamily
Domain Details Per Protein
Protein Length Axin-1 Axin-1/2, tankyrase-binding domain Axin beta-catenin binding Axin-like DIX domain DIX domain superfamily RGS domain RGS domain superfamily RGS, subdomain 1/3 Ubiquitin-like domain superfamily
UniProtKB:P57094 835
UniProtKB:A0A0R4II61 835
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations