Gene

notch2

ID
ZDB-GENE-000329-4
Name
notch receptor 2
Symbol
notch2 Nomenclature History
Previous Names
  • notch6
  • sb:cb884
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have Notch binding activity. Involved in several processes, including animal organ development; face morphogenesis; and lymphangiogenesis. Predicted to localize to integral component of membrane; nucleus; and plasma membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin; and splanchnocranium. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2).
Genome Resources
Note
None
Expression
All Expression Data
38 figures from 27 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With notch2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alagille syndrome Alliance Alagille syndrome 2 610205
Hajdu-Cheney syndrome Alliance Hajdu-Cheney syndrome 102500
Associated With notch2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000800 Notch domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR010660 Notch, NOD domain
Domain IPR011656 Notch, NODP domain
Domain IPR020683 Ankyrin repeat-containing domain
Domain IPR024600 Domain of unknown function DUF3454, notch
Family IPR008297 Notch
Family IPR022336 Neurogenic locus Notch 2
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR035993 Notch-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily Domain of unknown function DUF3454, notch EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Neurogenic locus Notch 2 Notch Notch domain Notch-like domain superfamily Notch, NOD domain Notch, NODP domain
UniProtKB:O42374 752
UniProtKB:Q90XX3 828
UniProtKB:F1RCH4 2475
UniProtKB:B0V2R4 2424
UniProtKB:O93617 735
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations