ZFIN ID: ZDB-GENE-000329-4
Gene Name: notch receptor 2
Gene Symbol: notch2    Nomenclature History

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Previous Names: notch6, sb:cb884

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and signaling receptor activity. Involved in several processes, including animal organ development; face morphogenesis; and lymphangiogenesis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin; and splanchnocranium. Orthologous to human NOTCH2 (notch receptor 2).
Genome Resources: Alliance (1),  Gene:58065 (1),  Ensembl(GRCz11):ENSDARG00000043130 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el515 Indel Unknown Premature Stop TALEN
el517 Small Deletion Exon 4 Frameshift, Premature Stop TALEN
la016287Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7129 Point Mutation Unknown Splice Site ENU
    sa25391 Point Mutation Unknown Premature Stop ENU
    sa31643 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34370 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34371 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38684 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41176 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41177 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH notch2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alagille syndrome Alliance Alagille syndrome 2 610205
    Hajdu-Cheney syndrome Alliance Hajdu-Cheney syndrome 102500
    DISEASE ASSOCIATED WITH notch2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development involved in endochondral bone morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR013032 EGF-like, conserved site
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    Domain IPR000742 EGF-like domain
    Domain IPR000800 Notch domain
    Domain IPR001881 EGF-like calcium-binding domain
    Domain IPR010660 Notch, NOD domain
    Domain IPR011656 Notch, NODP domain
    Domain IPR020683 Ankyrin repeat-containing domain
    Domain IPR024600 Domain of unknown function DUF3454, notch
    Family IPR008297 Notch
    Family IPR022336 Neurogenic locus Notch 2
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Homologous_superfamily IPR035993 Notch-like domain superfamily
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Repeat IPR002110 Ankyrin repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA notch2-201 (1)    Ensembl 10095
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM notch2 No data available
    MARKER RELATIONSHIPS
    notch2 Contained in: [BAC] CH73-281K2 (1), CH211-183C17 (1)
    notch2 Contains: [STS] chunp30626, unp109
    notch2 Encodes: [EST] cb884 (order this), eu314 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001115094 (1) 9828 nt
    Genomic GenBank:CT573380 (1) 124662 nt
    Select Tool
    Polypeptide UniProtKB:F1RCH4 (1) 2475 aa
    Sequence Information (all 23)
    ORTHOLOGY for notch2 ( Chr: 8 )
    CITATIONS (86)