ZFIN ID: ZDB-GENE-000329-4
Gene Name: notch 2
Gene Symbol: notch2
Sequence Ontology ID : SO:0000704

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Previous Names: notch6, sb:cb884

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(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 33 figures from 22 publications
Directly Submitted Expression Data: 6 figures (4 images) from Thisse et al., 2005 [eu314]
  6 figures (11 images) from Thisse et al., 2001 [cb884]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  brain, choroidal fissure, cleithrum, ectoderm (all 27) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el515 Indel Unknown Unknown TALEN
el517 Small Deletion Exon 4 Frameshift, Premature Stop TALEN
la016287Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7129 Point Mutation Unknown Splice Site ENU
    sa25391 Point Mutation Unknown Premature Stop ENU
    sa31643 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34370 Point Mutation Unknown Premature Stop ENU
    sa34371 Point Mutation Unknown Premature Stop ENU
    sa38684 Point Mutation Unknown Splice Site ENU
    sa41176 Point Mutation Unknown Splice Site ENU
    sa41177 Point Mutation Unknown Splice Site ENU
    Targeting reagents: CRISPR1-notch2 (1), CRISPR2-notch2 (1), CRISPR3-notch2 (2), CRISPR4-notch2 (2), CRISPR5-notch2 (2) (all 15) expand
    PHENOTYPE
    Data: 8 figures from 4 publications
    Observed in: endocrine pancreas, endocrine pancreas development, enteroendocrine cell differentiation, glucose homeostasis (all 11) expand
    DISEASE ASSOCIATED WITH notch2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Alagille syndrome Alagille syndrome 2 610205
    Hajdu-Cheney syndrome Hajdu-Cheney syndrome 102500
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cartilage development involved in endochondral bone morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000152 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR000800 (1)
  • InterPro:IPR001881 (1)
  • InterPro:IPR002110 (1)
  • InterPro:IPR008297 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR010660 (1)
  • InterPro:IPR011656 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR018097 (1)
  • InterPro:IPR020683 (1)
  • InterPro:IPR022336 (1)
  • InterPro:IPR024600 (1)
  • PROSITE:PS00010 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS01187 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50088 (1)
  • PROSITE:PS50258 (1)
  • PROSITE:PS50297 (1)
  • Pfam:PF00008 (1)
  • Pfam:PF00066 (1)
  • Pfam:PF06816 (1)
  • Pfam:PF07645 (1)
  • Pfam:PF07684 (1)
  • Pfam:PF11936 (1)
  • Pfam:PF12661 (1)
  • Pfam:PF12796 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA notch2-001 (1) 10095
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM notch2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    notch2Contained in: [BAC] CH73-281K2 (1) (order this), CH211-183C17 (1) (order this)
    notch2Contains: [STS] chunp30626, unp109
    notch2Encodes: [EST] cb884 (order this), eu314 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001115094 (1) 10095bp
    Genomic GenBank:CT573380 (1) 124662bp
    Select Tool
    Polypeptide UniProtKB:F1RCH4 (1) 2475aa
    Sequence Clusters UniGene:75826 (1)
    Sequence Information (all 24)
    OTHER notch2 GENE PAGES
  • Gene:58065 (1)
  • VEGA:OTTDARG00000032864 (1)
  • Ensembl(GRCz10):ENSDARG00000043130 (1)
  • ORTHOLOGY for notch2 (Chr: 8)
    CITATIONS (69)