Gene

notch2

ID
ZDB-GENE-000329-4
Name
notch receptor 2
Symbol
notch2 Nomenclature History
Previous Names
  • notch6
  • sb:cb884
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable Notch binding activity. Acts upstream of or within several processes, including face morphogenesis; lymphangiogenesis; and pancreas regeneration. Predicted to be located in nucleus and plasma membrane. Is expressed in several structures, including digestive system; mesoderm; nervous system; pectoral fin; and splanchnocranium. Human ortholog(s) of this gene implicated in Alagille syndrome and Hajdu-Cheney syndrome. Orthologous to human NOTCH2 (notch receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
40 figures from 29 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
9 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With notch2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Alagille syndrome Alliance Alagille syndrome 2 610205
Hajdu-Cheney syndrome Alliance Hajdu-Cheney syndrome 102500
Associated With notch2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000800 Notch domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR010660 Notch, NOD domain
Domain IPR011656 Notch, NODP domain
Domain IPR024600 Notch, C-terminal
Family IPR008297 Notch
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR035993 Notch-like domain superfamily
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain superfamily EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Notch Notch, C-terminal Notch domain Notch-like domain superfamily Notch, NOD domain Notch, NODP domain
UniProtKB:B0V2R4 2424
UniProtKB:F1RCH4 2475
UniProtKB:O42374 752
UniProtKB:Q90XX3 828
UniProtKB:O93617 735
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations