ZFIN ID: ZDB-GENE-000323-1
Gene Name: T-box brain transcription factor 1b
Gene Symbol: tbr1b    Nomenclature History

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Previous Names: tbr1, zf-tbr1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including generation of neurons; heart looping; and regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in nervous system and shield. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human TBR1 (T-box brain transcription factor 1).
Genome Resources: Alliance (1),  Gene:58042 (1),  Ensembl(GRCz11):ENSDARG00000004712 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb24 Small Deletion Unknown Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • ihb26 Small Deletion Unknown Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa10845 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34772 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41554 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH tbr1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Intellectual developmental disorder with autism and speech delay 606053
    DISEASE ASSOCIATED WITH tbr1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbr1b-201 (1)    Ensembl 3855
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbr1b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(tbr1:EYFP) tbr1b EYFP Danio rerio 2 5
    MARKER RELATIONSHIPS
    tbr1b Contained in: [Fosmid] CH1073-192A6 (1)
    tbr1b Encodes: [EST] eu258 (1)
    [cDNA] MGC:175170 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001115090 (1) 3028 nt
    Genomic GenBank:CU651665 (1) 37255 nt
    Select Tool
    Polypeptide UniProtKB:B5DE34 (1) 676 aa
    Sequence Information (all 16)
    ORTHOLOGY for tbr1b ( Chr: 9 )
    CITATIONS (55)