Gene

phox2a

ID
ZDB-GENE-000223-14
Name
paired like homeobox 2A
Symbol
phox2a Nomenclature History
Previous Names
  • sou (1)
  • arix (1)
  • soulless
  • zgc:77364
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in locus ceruleus development and noradrenergic neuron development. Predicted to localize to nuclear chromatin. Is expressed in several structures, including epibranchial field; hindbrain neural rod; midbrain hindbrain boundary neural keel; nervous system; and neural tube. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles. Orthologous to human PHOX2A (paired like homeobox 2A).
Genome Resources
Note
None
Expression
All Expression Data
35 figures from 20 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With phox2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital fibrosis of the extraocular muscles Alliance Fibrosis of extraocular muscles, congenital, 2 602078
Associated With phox2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR001356 Homeobox domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Domain Details Per Protein
Protein Length Homeobox, conserved site Homeobox domain Homeobox-like domain superfamily
UniProtKB:Q6NYV4 277
UniProtKB:F1RCT9 280
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations