ZFIN ID: ZDB-GENE-000223-14
Gene Name: paired like homeobox 2A
Gene Symbol: phox2a    Nomenclature History

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Previous Names: sou (1), arix (1), soulless, zgc:77364

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in locus ceruleus development and noradrenergic neuron development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles. Is expressed in several structures, including epibranchial field; hindbrain neural rod; midbrain hindbrain boundary neural keel; nervous system; and neural tube. Orthologous to human PHOX2A (paired like homeobox 2A).
Genome Resources: Alliance (1),  Gene:404602 (1),  Ensembl(GRCz11):ENSDARG00000007406 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
m810 Unknown Unknown Unknown ENU
m811 Point Mutation Unknown Missense ENU
m812 Point Mutation Unknown Missense ENU
DISEASE ASSOCIATED WITH phox2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital fibrosis of the extraocular muscles Alliance Fibrosis of extraocular muscles, congenital, 2 602078
DISEASE ASSOCIATED WITH phox2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process brain development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA phox2a-201 (1)    Ensembl 3891
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM phox2a No data available
MARKER RELATIONSHIPS
phox2a Contained in: [Fosmid] CH1073-119B3 (1)
phox2a Encodes: [cDNA] MGC:77364 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_207070 (1) 3930 nt
Genomic GenBank:CU633849 (1) 35786 nt
Select Tool
Polypeptide UniProtKB:F1RCT9 (1) 280 aa
Sequence Information (all 12)
ORTHOLOGY for phox2a ( Chr: 15 )
CITATIONS (47)