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ZIRC
ZFIN ID: ZDB-GENE-000210-6
Gene Name: twist family bHLH transcription factor 1a
Gene Symbol: twist1a
Sequence Ontology ID : SO:0001217

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Previous Names: twist-1, twist1, twist1b (2), wu:fd04c01, zgc:101115

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(Including Attributions)
Location: Chr: 19 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have protein dimerization activity. Involved in pharyngeal system development and sprouting angiogenesis. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome;  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el571 Small Deletion Unknown Unknown TALEN
sa10536 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25079 Point Mutation Unknown Premature Stop ENU
    Targeting reagents:
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH twist1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    craniosynostosis Craniosynostosis 1 123100
    Saethre-Chotzen syndrome Saethre-Chotzen syndrome with or without eyelid anomalies 101400
    Sweeney-Cox syndrome Sweeney-Cox syndrome 617746
    Robinow-Sorauf syndrome 180750
    DISEASE ASSOCIATED WITH twist1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pharyngeal system development (more)
    Molecular Function protein dimerization activity (more)
    GO Terms (all 3)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA twist1a-201 (1) 1148
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM twist1a
    MARKER RELATIONSHIPS
    twist1a Contained in: [Fosmid] CH1073-189B15 (1) (order this)
    twist1a Encodes: [EST] fd04c01 (1) (order this)
    [cDNA] MGC:101115 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130984 (1) 1151 bp
    Genomic GenBank:CU627989 (1) 36015 bp
    Select Tool
    Polypeptide UniProtKB:Q9PTE3 (1) 171 aa
    Sequence Clusters UniGene:79620 (1)
    Sequence Information (all 18)
    ORTHOLOGY for twist1a ( Chr: 19 )
    CITATIONS (52)