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ZIRC
ZFIN ID: ZDB-GENE-000210-32
Gene Name: NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1
Gene Symbol: nme2b.1    Nomenclature History

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Previous Names: NDPK-Z1, ndpkz1, NM23-B, NM23-Z1 (1), nm23b, nme1 (1), nme2, nme2b1 (1), nucleoside diphosphate kinase-Z1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Exhibits nucleoside diphosphate kinase activity. Involved in GTP biosynthetic process and regulation of angiogenesis. Human ortholog(s) of this gene implicated in neuroblastoma; ovary epithelial cancer; and teratoma. Is expressed in several structures, including digestive system; eye; gill; gonad; and heart. Orthologous to several human genes including NME1 (NME/NM23 nucleoside diphosphate kinase 1).
Genome Resources: Alliance (1),  Gene:30083 (1),  Ensembl(GRCz11):ENSDARG00000103791 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010760Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nme2b.1 N/A 1
    MO2-nme2b.1 N/A 4
    DISEASE ASSOCIATED WITH nme2b.1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nme2b.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process GTP biosynthetic process (more)
    Molecular Function nucleoside diphosphate kinase activity (more)
    GO Terms (all 14)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nme2b.1-003 (1) 709
    nme2b.1-004 (1) 519
    nme2b.1-201 (1)    Ensembl 619
    nme2b.1-202 (1)    Ensembl 676
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-nme2 polyclonal IgG Goat WB Santa Cruz Biotechnology, Inc.
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nme2b.1 No data available
    MARKER RELATIONSHIPS
    nme2b.1 Contained in: [Fosmid] CH1073-366L7 (1) (order this)
    nme2b.1 Encodes: [cDNA] MGC:66352 (1) (order this), MGC:192077 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130926 (1) 624 bp
    Genomic GenBank:CU694252 (1) 33871 bp
    Select Tool
    Polypeptide UniProtKB:A0A0N4STW1 (1) 164 aa
    Sequence Clusters UniGene:11052 (1)
    Sequence Information (all 32)
    ORTHOLOGY for nme2b.1 ( Chr: 19 )
    CITATIONS (38)