ZFIN ID: ZDB-GENE-000209-4
Gene Name: roundabout, axon guidance receptor, homolog 3 (Drosophila)
Gene Symbol: robo3
Previous Names: cb503 (1), twi, twitch twice (1)
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 29 figures from 14 publications
Directly Submitted Expression Data: 6 figures (24 images) from Thisse et al., 2001 [cb503]
  6 figures (31 images) from Thisse et al., 2008 [cssl:d102]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 6 (144.0h-168.0h)
  basal plate midbrain region, brain, central nervous system, cerebellum (all 44) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 12 Genotypes
Knockdown reagents: MO1-robo3 (1), MO2-robo3 (1), MO3-robo3 (1), MO4-robo3 (1), MO5-robo3 (1)

Allele Type Mutagen Suppliers
la027172Tg Transgenic Insertion DNA
sa13775 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tg224a Unknown ENU
  • Nüsslein-Volhard Lab
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw204 Point Mutation ENU
  • Nüsslein-Volhard Lab
  • European Zebrafish Resource Center (EZRC) (order this)
  • tx209 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Nüsslein-Volhard Lab
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 11 figures from 5 publications
    Observed in: axon midline choice point recognition, commissural neuron axon guidance, diencephalic nucleus axon, equilibrioception (all 17) expand

    Phenotype of Human Orthologue OMIM Phenotype ID
    Gaze palsy, horizontal, with progressive scoliosis 607313
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component integral component of plasma membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003598 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00041 (1)
  • Pfam:PF07679 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA robo3-001 (1) 5344
    robo3-002 (1) 5056
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM robo3 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    robo3 Contained in: [BAC] DKEY-30J19 (1) (order this), DKEY-77G18 (1) (order this), DKEY-119J14 (1) (order this)
    robo3 Encodes: [EST] cb503 (1) (order this), fb78e10
    [cDNA] cssl:d102 (1) (order this), MGC:194799 (1) (order this), MGC:194810 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131482 (1) 5358 bp
    Genomic GenBank:AL845320 (1) 183417 bp
    Select Tool
    Polypeptide UniProtKB:F1QFK4 (1) 1419 aa
    Sequence Clusters UniGene:77473 (1)
    Sequence Information (all 41)
    OTHER robo3 GENE PAGES
  • Gene:30770 (1)
  • VEGA:OTTDARG00000008424 (1)
  • Ensembl(Zv9):ENSDARG00000005645 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish robo3 10  
    Human ROBO3 11 (11q24.2)
  • OMIM:608630
  • Gene:64221
  • Mouse Robo3 9 ( 20.76 cM)
  • MGI:1343102
  • Gene:19649
  • Orthology Details
    CITATIONS (44)