ZFIN ID: ZDB-GENE-000209-4
Gene Name: roundabout, axon guidance receptor, homolog 3 (Drosophila)
Gene Symbol: robo3
Previous Names: cb503 (1), twi, twitch twice (1)
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 29 figures from 14 publications
Directly Submitted Expression Data: 6 figures (24 images) from Thisse et al., 2001 [cb503]
  6 figures (31 images) from Thisse et al., 2008 [cssl:d102]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 6 (144.0h-168.0h)
  basal plate midbrain region, brain, central nervous system, cerebellum (all 44) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027172Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13775 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tg224a Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tw204 Complex Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tx209 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-robo3 (1), MO2-robo3 (1), MO3-robo3 (1), MO4-robo3 (1), MO5-robo3 (1)
    PHENOTYPE
    Data: 11 figures from 5 publications
    Observed in: axon midline choice point recognition, commissural neuron axon guidance, diencephalic nucleus axon, equilibrioception (all 17) expand
    DISEASE ASSOCIATED WITH robo3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Gaze palsy, horizontal, with progressive scoliosis 607313
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component integral component of plasma membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003598 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013106 (1)
  • InterPro:IPR013783 (1)
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00041 (1)
  • Pfam:PF07679 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA robo3-001 (1) 5344
    robo3-002 (1) 5056
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM robo3
    Tg(hsp70l:robo3-001,EGFP), Tg(hsp70l:robo3-002,EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    robo3Contained in: [BAC] DKEY-30J19 (1) (order this), DKEY-77G18 (1) (order this), DKEY-119J14 (1) (order this)
    robo3Encodes: [EST] cb503 (1) (order this), fb78e10
    [cDNA] cssl:d102 (1) (order this), MGC:194799 (1) (order this), MGC:194810 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001328416 (1) 5398bp
    Genomic GenBank:AL845320 (1) 183417bp
    Select Tool
    Polypeptide UniProtKB:F1QFK4 (1) 1419aa
    Sequence Clusters UniGene:77473 (1)
    Sequence Information (all 43)
    OTHER robo3 GENE PAGES
  • Gene:30770 (1)
  • VEGA:OTTDARG00000008424 (1)
  • Ensembl(GRCz10):ENSDARG00000005645 (1)
  • ORTHOLOGY for robo3 (Chr: 10)
    Species Symbol Chromosome Accession # Evidence
    Human ROBO3 11
  • Gene:64221
  • OMIM:608630
  • HGNC:13433
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Robo3 9
  • MGI:1343102
  • Gene:19649
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (46)