Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-000209-4
Gene Name: roundabout, axon guidance receptor, homolog 3 (Drosophila)
Gene Symbol: robo3
Previous Names: cb503 (1), twi, twitch twice (1)
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 28 figures from 13 publications
Directly Submitted Expression Data: 6 figures (24 images) from Thisse et al., 2001 [cb503]
  6 figures (31 images) from Thisse et al., 2008 [cssl:d102]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  basal plate midbrain region, brain, central nervous system, cerebellum (all 42) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 12 genotypes
Alleles: la027172Tg, sa13775, tg224a, tw204, tx209
Knockdown reagents: MO1-robo3 (1), MO2-robo3 (1), MO3-robo3 (1), MO4-robo3 (1), MO5-robo3 (1)
PHENOTYPE
Data: 11 figures from 5 publications
Observed in: axon midline choice point recognition, commissural neuron axon guidance, diencephalic nucleus axon, equilibrioception (all 17) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Gaze palsy, horizontal, with progressive scoliosis 607313
GENE ONTOLOGY
Ontology GO Term
Biological Process axon guidance (more)
Cellular Component integral component of plasma membrane (more)
Molecular Function protein binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003598 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00041 (1)
  • Pfam:PF07679 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA robo3-001 (1) 5344
    robo3-002 (1) 5056
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM robo3 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    robo3 Contained in: [BAC] DKEY-30J19 (1), DKEY-77G18 (1), DKEY-119J14 (1)
    robo3 Encodes: [EST] cb503 (1) (order this), fb78e10
    [cDNA] cssl:d102 (1) (order this), MGC:194799 (1) (order this), MGC:194810 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131482 (1) 5358 bp
    Genomic GenBank:AL845320 (1) 183417 bp
    Select Tool
    Polypeptide UniProtKB:F1QFK4 (1) 1419 aa
    Sequence Clusters UniGene:77473 (1)
    Sequence Information (all 41)
    OTHER robo3 GENE PAGES
  • Gene:30770 (1)
  • VEGA:OTTDARG00000008424 (1)
  • Ensembl(Zv9):ENSDARG00000005645 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish robo3 10  
    Human ROBO3 11 (11q24.2)
  • OMIM:608630
  • Gene:64221
  • Mouse Robo3 9 ( 20.76 cM)
  • MGI:1343102
  • Gene:19649
  • Orthology Details
    CITATIONS (43)