ZFIN Gene: bmp7a

ZFIN ID: ZDB-GENE-000208-25

ZFIN ID: ZDB-GENE-000208-25

Gene Name:

bone morphogenetic protein 7a

Gene Symbol:

bmp7a Nomenclature History

Previous Names:

bmp7 (1), fb83f09, snailhouse, snh, wu:fb83f09 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 11 Mapping Details/Browsers

Description:

Exhibits identical protein binding activity and protein heterodimerization activity. Involved in several processes, including determination of bilateral symmetry; negative regulation of endodermal cell fate specification; and post-anal tail morphogenesis. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in prostate cancer. Is expressed in several structures, including epiphysis; gastrula cell; margin; prechordal plate; and tail bud. Orthologous to human BMP7 (bone morphogenetic protein 7).

Genome Resources:

Alliance (1), Gene:30584 (1), Ensembl(GRCz11):ENSDARG00000018260 (1)

GENE EXPRESSION
All Expression Data:	22 figures from 18 publications
Wild-type Stages, Structures:	Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
	blastoderm ventral region blastoderm ectoderm endoderm epiphysis gastrula cell margin neural plate anatomical region otic vesicle posterior region polster anatomical margin prechordal plate tail bud neural tube tail bud unspecified whole organism ventral region whole organism yolk syncytial layer
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
la012084Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
p11	Deficiency	Unknown	Unknown	G_RAYS
p15	Deficiency	Unknown	Unknown	G_RAYS
sa1343	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa15764	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sb1aub	Point Mutation	Unknown	Unknown	SPONTANEOUS	Zebrafish International Resource Center (ZIRC) (order this)
st1	Translocation	Unknown	Unknown	ENU
ty68a	Point Mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-bmp7a		1
CRISPR2-bmp7a		1
CRISPR3-bmp7a		1
MO1-bmp7a	N/A	7
MO2-bmp7a	N/A	6

PHENOTYPE

Data:

19 figures from 14 publications

Observed in:

DISEASE ASSOCIATED WITH bmp7a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH bmp7a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	determination of ventral identity (more)
Cellular Component	extracellular region (more)
Molecular Function	identical protein binding (more)

GO Terms (all 20)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	bmp7a-201 (1)	3384	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	bmp7a-202 (1)	973	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM bmp7a No data available

MARKER RELATIONSHIPS

bmp7a Contained in:	[BAC] CH211-253B8 (1) [Fosmid] CH1073-430F17 (1)
bmp7a Encodes:	[EST] fb83f09 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131321 (1)	1861 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR925817 (1)	156864 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q9PTF9 (1)	432 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 15)

ORTHOLOGY for bmp7a ( Chr: 11 )

CITATIONS (133)

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