ZFIN ID: ZDB-GENE-000201-9
Gene Name: anosmin 1a
Gene Symbol: anos1a    Nomenclature History

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Previous Names: anosmin-1a (1), kal1a, kal1.1, wu:fl91z45

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have peptidase inhibitor activity. Involved in neuron differentiation; olfactory bulb development; and posterior lateral line development. Predicted to localize to cell surface. Is expressed in several structures, including digestive system; nervous system; neural tube; otic vesicle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 1 with or without anosmia. Orthologous to human ANOS1 (anosmin 1).
Genome Resources: Alliance (1),  Gene:30630 (1),  Ensembl(GRCz11):ENSDARG00000012896 (2)
GENE EXPRESSION
All Expression Data: 28 figures from 8 publications
Directly Submitted Expression Data: 7 figures (9 images) from Thisse et al., 2004 [MGC:73357]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1160 Point Mutation Unknown Premature Stop ENU
sk50 Small Deletion Unknown Unknown TALEN
sk51 Small Deletion Unknown Unknown TALEN
zko613b Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-anos1a 1
    MO1-anos1a N/A 1
    MO2-anos1a N/A 2
    TALEN1-anos1a 1
    DISEASE ASSOCIATED WITH anos1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypogonadotropic hypogonadism 1 with or without anosmia Alliance Hypogonadotropic hypogonadism 1 with or without anosmia (Kallmann syndrome 1) 308700
    DISEASE ASSOCIATED WITH anos1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process posterior lateral line neuromast primordium migration (more)
    Cellular Component extracellular region (more)
    Molecular Function peptidase inhibitor activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA anos1a-201 (1)    Ensembl 2392
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-anos1a polyclonal Rabbit IHC, WB 3
    Ab2-anos1a polyclonal Rabbit IHC 3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM anos1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tgbac(anos1a:egfp-anos1a,cryaa:dsred) anos1acryaa anos1aDsRedEGFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    anos1a Contained in: [BAC] CH211-157N19 (1), DKEY-148E3 (1) (order this)
    anos1a Encodes: [EST] fl91z45
    [cDNA] MGC:73357 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131358 (1)
    Genomic GenBank:BX901898 (1) 249378 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0B5JS68 (1) 652 aa
    Sequence Information (all 18)
    ORTHOLOGY for anos1a ( Chr: 1 )
    CITATIONS (31)