Gene

dlc

ID
ZDB-GENE-000125-4
Name
deltaC
Symbol
dlc Nomenclature History
Previous Names
  • bea
  • beamter
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Exhibits PDZ domain binding activity and identical protein binding activity. Involved in several processes, including blood vessel development; neuron differentiation; and somite development. Localizes to perinuclear region of cytoplasm and plasma membrane. Is expressed in several structures, including immature eye; integument; mesoderm; nervous system; and trunk. Human ortholog(s) of this gene implicated in dysostosis and spondylocostal dysostosis. Orthologous to human DLL1 (delta like canonical Notch ligand 1) and DLL3 (delta like canonical Notch ligand 3).
Genome Resources
Note
None
Expression
All Expression Data
163 figures from 99 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
18 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dlc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylocostal dysostosis Alliance Spondylocostal dysostosis 1, autosomal recessive 277300
Associated With dlc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
Domain IPR001881 EGF-like calcium-binding domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily
UniProtKB:A0A2R8QUE3 677
UniProtKB:Q9IAT6 664
UniProtKB:A4JYS0 664
UniProtKB:B3DFM3 664
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations