FIGURE

Fig. 2

ID

ZDB-FIG-230801-3

Publication

Wilson et al., 2022 - Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos

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Fig. 2

Exocrine pancreas area. Tg(ptf1a::GFP) zebrafish embryos were imaged and measured at 96 hpf following exposure to 50 nM tris(4-chlorophenyl)methanol (TCPMOH), 50 nM tris(4-chlorophenyl)methane (TCPM), or 0.01% DMSO. Asterisks (*) designate statistically significant changes from controls (p < .05). n = 26–32 embryos per exposure group. (a) Mean exocrine pancreas area of embryos exposed to 50 nM TCPMOH and 50 nM TCPM were reduced by 13% and 8.8%, respectively, compared to controls. (b) Incidence of hypomorphic pancreases was significantly increased in TCPMOH-exposed embryos, accounting for one-third of those exposed.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Birth Defects Res