FIGURE

Fig. 1

ID

ZDB-FIG-230626-2

Publication

Smith et al., 2023 - Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart

Other Figures

Fig. 1

All Figure Page

Back to All Figure Page

Fig. 1

Summary of cardiac phenotypes observed in wildtype and TMEM161B knockout (KO) mouse embryos. At 14.5 dpc, TMEM161B KO embryos have VSDs and atrial and ventricular defects (AVSD, cyan asterisks). At 17.5 dpc, TMEM161B KO embryo hearts have altered morphology (although no reported VSD or AVSD), with thickened interventricular septum (cyan scale bar) and increased cell number. Isolated cardiomyocytes exhibit altered Ca.²⁺ oscillation, compared with wildtype littermates. At 18.5 dpc, the ventricular walls of TMEM161B KO embryonic hearts are considerable thicker (cyan scale bars) and, in some instances, almost entirely occlude the chamber lumen. Phenotypic summary derived from published data (Koopman et al. 2021; Spielmann et al. 2022) and IMPC data (http://www.mousephenotype.org/data/embryo)

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Mamm. Genome