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FIGURE 2
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- ZDB-FIG-221109-2
- Publication
- Pardon et al., 2022 - Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor
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FIGURE 2
Representative IP-One dose response curves for antagonists EMPA, Suvorexant, SB 674042 and TCS 1102 on human OX2R (purple), zebrafish OX2R (blue) and hOX2R (T111S, I130L, V353I) (green). Antagonists were incubated for 30 min at 37°C and subsequently the cells were stimulated with 1 µM of reference agonist C14917. Cells were incubated for 2 more hours and subsequently readout was performed. Dose responses were performed as technical duplicates, data were normalized to 10 µM of reference agonist C14917. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
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