FIGURE

Fig. 7

ID

ZDB-FIG-220512-22

Publication

Xue et al., 2019 - Novel cathepsin K inhibitors block osteoclasts in vitro and increase spinal bone density in zebrafish

Other Figures

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Fig. 7

Therapeutic effect of A22 in OP zebrafish. (A) Zebrafish spine fluorescence intensity data were collected within the white rectangle area. A22 was administered at a dose of 0.11 μM, 0.33 μM, 1.00 μM, and etidronate disodium (ED) was administered at a dose of 600 μM; (B) spine fluorescence intensity data were calculated based on values obtained from 30 fish each group. (C) A22 therapeutic effect on zebrafish OP. ***Differences from the model group with probability p < 0.001. The p value is calculated using Dunnett's T test and differences with probability p < 0.05 are considered statistically significant.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Condition:	chemical treatment by environment: etidronate disodium
Observed In:	bone mineralization
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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