FIGURE

Figure 6.

ID

ZDB-FIG-220326-18

Publication

Vasileva et al., 2022 - Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

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Figure 6.

Surfen treatment impairs ERK1/2 signaling and growth of Ewing sarcoma cells.

(A) Immunoblot analysis of pERK1/2, ERK1/2, and tubulin levels in TC32 and EWS502 cells treated with surfen or DMSO. (B) Immunoblot quantification of pERK1/2 expression level relative to ERK1/2 in TC32 and EWS502 cells treated with surfen or DMSO vehicle control. Error bars represent standard error of the mean (SEM), N = 3, *p < 0.05, **p < 0.01, based on one-way analysis of variance (ANOVA) test. (C) Proliferation rates of TC32 and EWS502 cells treated with surfen or DMSO. Error bars represent SEM, N = 3, **p < 0.01, ***p < 0.001, ****p < 0.0001 based on one-way ANOVA test. (D) Morphological changes in TC32 and EWS502 cells after surfen or DMSO treatment. (E) Clonogenic assay and (F) clonogenic assay quantification of TC32 and EWS502 cells treated with surfen or DMSO. Error bars represent SEM, N = 4, ***p < 0.001, ****p < 0.0001 based on one-way ANOVA test.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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