FIGURE

Fig. 10

ID

ZDB-FIG-220131-573

Publication

Bergen et al., 2022 - Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease

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Fig. 10

Histomorphology and tissue mineral density measurements on 3D micro-CT images of spp1^P160X and col11a2^Y228X homozygous mutants revealed altered bone structures. A Lower jaw size was reduced in col11a2 mutants (one-way ANOVA: length: (f(2) = 33.38, p< 0.0001), width: (f(2) = 15.06, p< 0.0001)). B A one-way ANOVA (f(2) = 3.636, p< 0.05) analysis indicated that lower jaw element proportions showed an altered tendency in both mutants. C Ventral view of the segmented lower jaw images. Orange arrow indicates anterior mandibular arch joint and blue arrow shows mandibular arch—palatoquadrate (not visible) joint. D Lateral view of segmented images of the first caudal vertebra showing the anterior facet (orange arrow) and haemal arch (blue arrow). E Mean tissue mineral density (TMD) calculations and one-way ANOVA analysis of dermal parietal skull (f(2) = 4.144, p< 0.05) and notochord sheath derived vertebral (p=0.077) bone. Tukey’s multiple comparison p-values are shown on the graphs

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Biol.