Figure 5
- ID
- ZDB-FIG-210902-214
- Publication
- Hentig et al., 2021 - Zebrafish Blunt-Force TBI Induces Heterogenous Injury Pathologies That Mimic Human TBI and Responds with Sonic Hedgehog-Dependent Cell Proliferation across the Neuroaxis
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Apoptotic cell-death in cerebellar neurons. (A–B’’’) Confocal images of coronal cerebellar sections stained with pan-neuronal marker HuCD (gray), fluorescent TUNEL (red), and DAPI (DAPI) at 16 h follow a sTBI. Apoptotic cell death was observed in the epicenter of the impact zone, in the densely packed granule layer of the cerebellum. (C–E’’’’) High magnification confocal images revealed colabelling of HuCD, TUNEL, and DAPI. The white box in panels (A–A’’’) represent the region that is shown in corresponding panels (B–B’’’). Lettered white boxes in panels (B–B’’’) denote subsequent panels at higher magnification. A solid line denotes tissue boarder, dotted line denotes boarder between molecular and granule layer of the CCe. Cerebellar crest, CC, granule cell layer, GL, molecular layer, ML. Scale bars, (A) = 100 µm, for panels (A–A’’’,B) = 50 µm, for panels (B–B’’’,C) = 15 µm, for panels (C–E’’’’). |