FIGURE

Figure 2

ID

ZDB-FIG-201130-32

Publication

Lai et al., 2020 - Duplicated dnmt3aa and dnmt3ab DNA Methyltransferase Genes Play Essential and Non-Overlapped Functions on Modulating Behavioral Control in Zebrafish

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Figure 2

Morphometric and DNA methylation level comparison for wild types, dnmt3aa, and dnmt3ab gene knockout zebrafish. (A) Morphologies of six-month-old wild types, dnmt3aa, and dnmt3ab knockout zebrafish. Female fish is shown in the upper panel and male fish in the bottom panel. (B) Morphometric analysis of wild types, dnmt3aa, and dnmt3ab gene knockout zebrafish by principal component analysis (PCA) method. (C) Schematic diagram showing the biochemical pathway on key proteins involving cytosine DNA methylation. Comparison of 5-hmC (D), 5-mC (E), and 5-hmC/5-mC ratio (F) between wild types, dnmt3aa, and dnmt3ab knockout zebrafish. The data are expressed as the mean with S.E.M. and analyzed by one-way ANOVA followed by Fisher’s LSD post hoc test (n = 6 for wild type; n = 4 for dnmt3aa KO fish; n = 5 for dnmt3ab KO fish).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dnmt3aa^cy53/cy53 dnmt3ab^cy54/cy54
Observed In:	whole organism whole organism 5-(hydroxymethyl)cytosine whole organism 5-methylcytosine
Stage:	Adult

Phenotype Detail

Acknowledgments

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