ZFIN ID: ZDB-FIG-200724-26
Lee et al., 2020 - Human ARF Specifically Inhibits Epimorphic Regeneration in the Zebrafish Heart. Genes   11(6) Full text @ Genes (Basel)
Anatomical Term:
Stage: Adult
Observed In:
Stage: Adult

Figure 2

ARF expressed under control of the endogenous human ARF promoter in ARF:ARF fish suppresses cardiac regeneration over time. (a) AFOG and troponin staining of WT and ARF:ARF heart cryosections at 1, 7, 15, and 30 dpi. The dotted lines demarcate the injury site. Red stains are for fibrin. Blue stains are for collagen. Brown stains are for muscle. Green stains are for troponin. (b) Myocardial recovery measured by troponin infiltration into the injury site. Infiltration quantified by imaging software shows decreased troponin in the injury site of ARF:ARF fish compared to WT fish from 7 dpi onward. N = 49 hearts. The grey and black lines are logarithmic approximations of the WT and ARF:ARF heart recovery trends respectively. Results are shown as mean ± standard error. The * represents a statistically significant difference.

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab7-tnnt IHC zf707Tg(AB) cold damage: heart Adult heart regenerating tissue
Phenotype Details
Fish Conditions Stage Phenotype
zf707Tg(AB) cold damage: heart Adult heart cardiac muscle tissue regeneration disrupted, abnormal
Adult heart regenerating tissue Ab7-tnnt labeling decreased amount, abnormal
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