FIGURE

Fig. 2

ID

ZDB-FIG-200217-3

Publication

Singh et al., 2019 - αKlotho Regulates Age-Associated Vascular Calcification and Lifespan in Zebrafish

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Fig. 2

Vascular Calcification and Inflammation in αklothoMutants

H&E staining on paraffin sections from 5-month-old wild-type control (Tü) and αklotho (klΔ5) males. Shown are (A) skin (arrows indicate mucous cells in wild type); (B) muscle (arrows indicate vascular calcification); (C) gills; (D) heart (arrow indicates calcification in the BA); (D′ and D″) alizarin red-stained whole-mount hearts (arrows indicate the BA); (E) BA (arrow indicates calcification); (F) liver (arrows indicate bile-duct); and (G) kidney (arrows indicate glomeruli). (H) Bright-field images of 5-mpf wild-type (left) and klΔ5 (right) hearts. TRAP staining on (I) whole mount and (J) cryosection of 5-mpf hearts.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kl^{zf3212/zf3212} (TU)
Observed In:	bone tissue bulbus arteriosus bulbus arteriosus osteoclast common bile duct dermis dermis vasculature epidermis pharyngeal arch 3-7 skeletal muscle skeletal muscle vasculature whole organism whole organism inflammatory response
Stage:	Adult

Phenotype Detail

Acknowledgments

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