FIGURE

Figure 3.

ID

ZDB-FIG-200210-40

Publication

Nagashima et al., 2019 - Midkine-a is required for cell cycle progression of Müller glia glia during neuronal regeneration in the vertebrate retina

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Figure 3.

Some Müller glia in the mdka^mi5001 progress through the cell cycle. A, B, BrdU labeling between 48 and 72 hpl in WT and mdka^mi5001 mutant retinas. In WT, Müller glia-derived progenitors are labeled with BrdU. In mdka^mi5001 mutant at 72 hpl, fewer cells in the inner nuclear layer (INL) and outer nuclear layer (ONL) are labeled with BrdU compared with WT (INL: p < 0.0001; ONL: p = 0.0008, ANOVA with post hoc Tukey). C, BrdU labeling (green) in transgenic reporter line, Tg(gfap:eGFP)^mi2002, in the mdka^mi5001 mutant background. Tg(gfap:eGFP)^mi2002 is pseudocolored in magenta. Scale bar, 30 μm. *p < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	mdka^{mi5001/mi5001} (AB) mdka^{mi5001/mi5001}; mi2002Tg
Condition:	light damage: eye photoreceptor cell
Observed In:	Muller cell cell population proliferation retinal inner nuclear layer cell population proliferation retinal outer nuclear layer cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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