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Differential gene expression between heterozygous mutant (<italic>psen1</italic><sup><italic>K97fs/+</italic></sup>) and wild type (<italic>psen1</italic><sup>+/+</sup>) zebrafish brains at 6 months (young) and 24 months (aged).Only genes with absolute log2 fold change > 0.5 are shown. Genes were considered differentially expressed if their moderated t-test FDR-adjusted p-value was below 0.05. (A) Differentially expressed genes at 6 months. (B) Differentially expressed genes at 24 months. The differentially expressed genes are grouped into clusters based on gene expression changes across the four comparisons. Overall, note the similar expression changes in ‘young heterozygous mutant vs. young wild type’ and ‘aged wild-type vs. young wild-type’ and the contrast of these to comparisons involving aged heterozygous mutants. This illustrates the accelerated brain aging in young heterozygous mutant brains and the "inverted" gene expression pattern of aged heterozygous mutant brains.
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