FIGURE

Figure 1.

ID

ZDB-FIG-190723-258

Publication

Glenn et al., 2019 - How muscle contraction strengthens tendons

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Figure 1.

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Figure 1.

Muscle contraction is required for normal tendon development.

(A) During normal muscle development, contractions increase the amount of extracellular matrix proteins, including collagen (green) and Thrombospondin (red), deposited in the developing tendon. These muscle contractions are also required for normal BMP signaling that prompts tenocytes (tendon precursor cells, blue) to elongate and extend complex protrusions (inset panels). (B) In the absence of muscle contraction, extracellular matrix deposition is decreased and tenocytes are rounded with shorter and less complex protrusions.

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