FIGURE

Figure 3

ID

ZDB-FIG-190723-1328

Publication

Xie et al., 2019 - Semisynthetic aurones inhibit tubulin polymerization at the colchicine-binding site and repress PC-3 tumor xenografts in nude mice and myc-induced T-ALL in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Figure 3

(A,B) Aurone 5a induced cell cycle arrest. (C) Aurone 5a decreased tubulin polymerization. (D) Aurone 5a (5 µM) and colchicine (5 µM) inhibited tubulin polymerization in vitro in a similar fashion. (E) Competitive tubulin binding assay with colchicine in the presence of increasing concentrations of aurones 5a. (F–H) Aurone 5a treatment (6 h) inhibited microtubule structures and caused cell morphology change in PC-3 cells as shown in panels F, DMSO; G, 5a (1 µM); H, 5a (300 nM). Red immunofluorescence: α-tubulin; blue: DAPI.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Sci. Rep.