ZFIN ID: ZDB-FIG-190501-169
Guissart et al., 2018 - Dual Molecular Effects of Dominant RORA Mutations Cause Two Variants of Syndromic Intellectual Disability with Either Autism or Cerebellar Ataxia. American journal of human genetics   102:744-759 Full text @ Am. J. Hum. Genet.
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Gene:
Antibodies:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Protruding-mouth
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Protruding-mouth

Fig. 3 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP nl1Tg control Protruding-mouth cerebellar granule cell IHC
nl1Tg + CRISPR2-roraa standard conditions Protruding-mouth cerebellar granule cell IHC
nl1Tg + MO1-roraa standard conditions Protruding-mouth cerebellar granule cell IHC
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Anatomy
Ab1-aldoc IHC nl1Tg control Protruding-mouth Purkinje cell
IHC nl1Tg + CRISPR2-roraa standard conditions Protruding-mouth Purkinje cell
IHC nl1Tg + MO1-roraa standard conditions Protruding-mouth Purkinje cell
Ab1-tuba IHC WT + CRISPR1-roraa standard conditions Protruding-mouth cerebellum axon
IHC Protruding-mouth intertectal commissure
IHC Protruding-mouth optic tectum axon
IHC WT + CRISPR2-roraa standard conditions Protruding-mouth cerebellum axon
IHC Protruding-mouth intertectal commissure
IHC Protruding-mouth optic tectum axon
IHC WT + MO1-roraa standard conditions Protruding-mouth cerebellum axon
IHC Protruding-mouth intertectal commissure
IHC Protruding-mouth optic tectum axon
IHC WT + MO2-roraa standard conditions Protruding-mouth cerebellum axon
IHC Protruding-mouth intertectal commissure
IHC Protruding-mouth optic tectum axon
Phenotype Details
Fish Conditions Stage Phenotype
WT + CRISPR1-roraa standard conditions Protruding-mouth cerebellum decreased area, abnormal
Protruding-mouth cerebellum morphogenesis decreased process quality, abnormal
WT + CRISPR2-roraa standard conditions Protruding-mouth cerebellum decreased area, abnormal
Protruding-mouth cerebellum morphogenesis decreased process quality, abnormal
WT + MO1-roraa standard conditions Protruding-mouth cerebellum decreased area, abnormal
Protruding-mouth cerebellum morphogenesis decreased process quality, abnormal
WT + MO2-roraa standard conditions Protruding-mouth cerebellum decreased area, abnormal
Protruding-mouth cerebellum morphogenesis decreased process quality, abnormal
nl1Tg + CRISPR2-roraa standard conditions Protruding-mouth cerebellum has fewer parts of type cerebellar granule cell, abnormal
Protruding-mouth cerebellum has fewer parts of type Purkinje cell, abnormal
Protruding-mouth cerebellum morphogenesis decreased process quality, abnormal
nl1Tg + MO1-roraa standard conditions Protruding-mouth cerebellum has fewer parts of type cerebellar granule cell, abnormal
Protruding-mouth cerebellum has fewer parts of type Purkinje cell, abnormal
Protruding-mouth cerebellum morphogenesis decreased process quality, abnormal
Full text @ Am. J. Hum. Genet.