FIGURE

Fig. 2-S2

ID

ZDB-FIG-180730-20

Publication

Vinayagam et al., 2018 - Electron cryo-microscopy structure of the canonical TRPC4 ion channel

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Fig. 2-S2

Cryo-EM structure of TRPC4_DR.

(a-b) Representative digital micrograph area (a) and selected 2-D class averages (b) of TRPC4_DR embedded in vitrified ice. Scale bars, 50 nm (a), and 10 nm (b). (c) The ab initio 3-D reconstruction obtained with RVIPER. (d) Angular distribution of the particles. (e) The cryo-EM density map of TRPC4_DR colored according to the local resolution. (f) Fourier Shell Correlation (FSC) curve between maps from two independently refined half data sets (black). The 0.143 criterion indicates an average resolution of 3.6 Å. The grey curve shows the FSC curve between the final map versus the atomic model. (g) Representative regions of the density with fitted atomic model.

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