ZFIN ID: ZDB-FIG-180711-73
Kontarakis et al., 2018 - Mir-126 is a conserved modulator of lymphatic development. Developmental Biology   437(2):120-130 Full text @ Dev. Biol.
Knockdown Reagent:
Observed In:
Stage Range: Long-pec to Protruding-mouth

Fig. S7

Vascular integrity is not obviously affected in mir-126 mutant embryos or mir-126; egfl7 compound mutants. (A,B) Injection of 16 or 20 ng of mir-126 MO results in brain haemorrhage by 48 hpf. (C) On the contrary, analysis of a population of mir-126 mutant larvae reveals a small fraction of larvae (not exclusively double mutant) exhibiting brain haemorrhage. Left and right graphs are for egfl7 mutant and wild-type backgrounds, respectively.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-mir126 standard conditions Long-pec brain hemorrhagic, abnormal
mir126abns2/bns2; mir126bbns3/bns3 standard conditions Protruding-mouth brain hemorrhagic, abnormal
mir126abns2/bns2; mir126bbns3/bns3; egfl7s981/s981 standard conditions Protruding-mouth brain hemorrhagic, abnormal
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Reprinted from Developmental Biology, 437(2), Kontarakis, Z., Rossi, A., Ramas, S., Dellinger, M.T., Stainier, D.Y.R., Mir-126 is a conserved modulator of lymphatic development, 120-130, Copyright (2018) with permission from Elsevier. Full text @ Dev. Biol.