FIGURE

Fig. 5

ID

ZDB-FIG-180710-13

Publication

Agalou et al., 2018 - Identification of Novel Melanin Synthesis Inhibitors From Crataegus pycnoloba Using an in Vivo Zebrafish Phenotypic Assay.

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Fig. 5

Isolated compounds from the dibenzofuran family repress reversibly in vivo pigmentation in zebrafish. Embryos were pretreated at 24 hpf with 0.01 mg/mL test compounds for 24 h. At 48 hpf pigmentation levels were recorded (A–F) and the embryos were divided into two groups. One group was washed and bathed immediately in fresh medium, whereas the other group was incubated with dibenzofuran compounds for further 24 h. At 72 hpf, the effect on melanogenesis was assessed using a stereomicroscope for both the compound treatment stopped group (G–L) and the embryos that were continuously treated with the dibenzofuran compounds for 48 h (M–R). PTU (E,K,Q) and DMSO (F,L,R) were used as positive and negative controls, respectively. (S) A schematic representation for the schedule of pigmentation rescue study. Scale bar: 100 μM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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