FIGURE
Fig. 1
- ID
- ZDB-FIG-180130-20
- Publication
- Banerji et al., 2017 - How many roads lead to cohesinopathies?
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Fig. 1
DNA tethering mechanisms of cohesins and auxiliary factors. Schematic representation of the cohesin ring structure (composed of the five subunits: SMC1A, SMC3, RAD21, SA1,2, and PDS5) and auxiliary factors NIPBL (loader), ESCO2 (acetyltransferase), and HDAC8 (deacetylase). Cohesins and auxiliary factors regulate both cis- and trans-DNA tethering events. Cis-DNA tethering processes include DNA looping mechanisms during transcription, condensation, and ribosome biogenesis. Trans-DNA tethering processes include sister chromatid segregation during S phase of cell cycle and DNA repair events. |
Expression Data
Expression Detail
Antibody Labeling
Phenotype Data
Phenotype Detail
Acknowledgments
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