ZFIN ID: ZDB-FIG-161027-9
Cox et al., 2016 - Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America   113(38):E5562-71 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage Range: Day 5 to Days 14-20

Fig. 1

seph mutant zebrafish exhibit defects in organ development. (A) Schematic illustrating the nature of the seph mutant. (B) Survival of WT and homozygous seph mutant larvae over time. n = 160 larvae. (C) Morphological assessment and fluorescent imaging (lateral and ventral views) of WT and seph mutant larvae on a Tg(ela3l:GFP;fabp10a:dsRed) background by confocal tomography at 5 dpf. Liver volume: WT, 3.09e6 µm3; seph, 1.69e6 µm3. Pancreas volume: WT, 2.79e6 µm3; seph, undetectable. (Scale bar: 100 µm.) (D) Quantitative analysis of fluorescent liver area in WT and seph mutant larvae at 5 dpf. n = 16. ****P < 0.0001. (E) Quantitative analysis of fluorescent pancreas area in WT and seph mutant larvae at 5 dpf. n = 16. ****P < 0.0001.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
selenohhi2737Tg/hi2737Tg standard conditions Days 7-13 - Days 14-20 whole organism dead, abnormal
Days 7-13 - Days 14-20 whole organism decreased life span, abnormal
selenohhi2737Tg/hi2737Tg; gz15Tg standard conditions Day 5 eye decreased size, abnormal
Day 5 liver decreased size, abnormal
Day 5 pancreas absent, abnormal
Day 5 pancreas decreased size, abnormal
Day 5 swim bladder uninflated, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Proceedings of the National Academy of Sciences of the United States of America for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Proc. Natl. Acad. Sci. USA