FIGURE

Fig. 3

ID

ZDB-FIG-160330-6

Publication

Liu et al., 2016 - Irf6 directly regulates Klf17 in zebrafish periderm and Klf4 in murine oral epithelium, and dominant-negative KLF4 variants are present in patients with cleft lip and palate

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Fig. 3

Rare NSCL/P alleles of KLF4 disrupt development of the zebrafish periderm. (A) Schematic representation of KLF4 protein. Positions of the rare, patient-derived variants predicted to be damaging by PolyPhen and SIFT are indicated above, and that of the common variant is indicated below. (B) Pedigrees of families with KLF4 p.S284L and p.H427Y variants. (C-I) Dorsal views of embryos, injected with the indicated mRNA and fixed at 5 hpf and processed to reveal (C-G) krt4 expression or (H and I) phalloidin stain. Arrows indicate periderm lacking phalloidin stain. (J) Quantification of embryos that died around 6 hpf when injected with the indicated mRNA. The numbers in parentheses indicate the total number of embryos for each group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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