ZFIN ID: ZDB-FIG-151109-9
Fitzgerald et al., 2015 - Large-scale discovery of novel genetic causes of developmental disorders. Nature   519(7542):223-228 Full text @ Nature
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage Range: Prim-5 to Day 5

Fig. S7 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-btbd9 standard conditions Long-pec brain decreased size, abnormal
Long-pec head decreased size, abnormal
Long-pec heart edematous, abnormal
Long-pec heart morphology, abnormal
Long-pec trunk curved dorsal, abnormal
Long-pec whole organism anatomical axis decreased size, abnormal
Long-pec whole organism decreased size, abnormal
WT + MO1-cnot1 standard conditions Prim-5 otic vesicle decreased size, abnormal
Prim-5 otic vesicle malformed, abnormal
Prim-5 trunk curved ventral, abnormal
Prim-5 whole organism decreased size, abnormal
Long-pec otic vesicle malformed, abnormal
Long-pec whole organism anatomical axis decreased size, abnormal
WT + MO1-ddx3xb standard conditions Long-pec brain decreased size, abnormal
Long-pec eye decreased size, abnormal
Long-pec eye morphology, abnormal
Long-pec head decreased size, abnormal
Long-pec pericardium edematous, abnormal
Long-pec trunk curved ventral, abnormal
Long-pec whole organism anatomical axis decreased length, abnormal
Long-pec whole organism decreased size, abnormal
WT + MO1-dpep2 standard conditions Long-pec eye decreased size, abnormal
Long-pec head decreased size, abnormal
Long-pec pericardium edematous, abnormal
Long-pec trunk curved ventral, abnormal
WT + MO1-dtwd2 standard conditions Prim-5 head morphology, abnormal
Prim-5 somite morphology, abnormal
Prim-5 whole organism anatomical axis decreased length, abnormal
Prim-5 whole organism apoptotic, abnormal
Long-pec somite morphology, abnormal
Long-pec trunk bent, abnormal
Long-pec whole organism apoptotic, abnormal
WT + MO1-etf1b standard conditions Prim-5 central nervous system decreased thickness, abnormal
Prim-5 notochord bent, abnormal
Prim-5 trunk curved ventral, abnormal
Prim-5 whole organism decreased size, abnormal
Prim-5 whole organism morphology, abnormal
Long-pec brain decreased size, abnormal
Long-pec eye decreased size, abnormal
Long-pec head decreased size, abnormal
Protruding-mouth eye decreased size, abnormal
Protruding-mouth head decreased size, abnormal
WT + MO1-fryl standard conditions Long-pec heart morphology, abnormal
Long-pec pericardium edematous, abnormal
Long-pec whole organism anatomical axis decreased length, abnormal
Protruding-mouth head malformed, abnormal
Protruding-mouth heart morphology, abnormal
Protruding-mouth pericardium edematous, abnormal
WT + MO1-ilvbl standard conditions Prim-5 trunk absent, abnormal
Prim-5 whole organism apoptotic, abnormal
Prim-5 whole organism decreased size, abnormal
Long-pec head edematous, abnormal
Long-pec head malformed, abnormal
Long-pec trunk malformed, abnormal
Long-pec whole organism anatomical axis decreased length, abnormal
Day 5 head malformed, abnormal
WT + MO1-nono standard conditions Prim-5 brain decreased size, abnormal
Prim-5 central nervous system decreased size, abnormal
Prim-5 embryo development arrested, abnormal
Prim-5 eye decreased size, abnormal
Prim-5 head decreased size, abnormal
Prim-5 otic vesicle decreased size, abnormal
Prim-5 pericardium decreased size, abnormal
Prim-5 somite absent, abnormal
Prim-5 somite morphology, abnormal
Prim-5 trunk decreased length, abnormal
Prim-5 trunk increased thickness, abnormal
Prim-5 whole organism apoptotic, abnormal
Prim-5 whole organism morphology, abnormal
WT + MO1-pkn2a standard conditions Long-pec brain edematous, abnormal
Long-pec eye decreased size, abnormal
Long-pec heart morphology, abnormal
Long-pec melanocyte decreased amount, abnormal
Long-pec pericardium edematous, abnormal
Protruding-mouth head decreased size, abnormal
Protruding-mouth head morphology, abnormal
Protruding-mouth heart morphology, abnormal
Protruding-mouth pericardium edematous, abnormal
Protruding-mouth trunk curved ventral, abnormal
Protruding-mouth whole organism anatomical axis decreased length, abnormal
Day 5 cranial cartilage absent, abnormal
Day 5 cranial cartilage decreased size, abnormal
Day 5 head malformed, abnormal
Day 5 ventral mandibular arch decreased size, abnormal
WT + MO1-pogza standard conditions Long-pec brain decreased size, abnormal
Long-pec brain edematous, abnormal
Long-pec central nervous system decreased thickness, abnormal
Long-pec eye decreased size, abnormal
Long-pec head decreased size, abnormal
Long-pec melanocyte decreased amount, abnormal
Long-pec otic vesicle decreased size, abnormal
Long-pec pericardium edematous, abnormal
Long-pec spinal cord decreased size, abnormal
Long-pec spinal cord decreased thickness, abnormal
Long-pec trunk curved ventral, abnormal
Long-pec trunk necrotic, abnormal
Long-pec whole organism decreased size, abnormal
Long-pec yolk edematous, abnormal
WT + MO1-psd2 standard conditions Long-pec brain edematous, abnormal
Long-pec eye decreased size, abnormal
Long-pec head decreased size, abnormal
Long-pec heart morphology, abnormal
Long-pec larval locomotory behavior process quality, abnormal
Long-pec pericardium edematous, abnormal
Long-pec somite morphology, abnormal
Long-pec spinal cord decreased thickness, abnormal
Long-pec trunk curved ventral, abnormal
Long-pec whole organism decreased size, abnormal
WT + MO1-psmd3 standard conditions Prim-5 otic vesicle decreased size, abnormal
Long-pec brain edematous, abnormal
Long-pec brain morphology, abnormal
Long-pec floor plate absent, abnormal
Long-pec head decreased size, abnormal
Long-pec head morphology, abnormal
Long-pec otic vesicle decreased size, abnormal
Long-pec otolith decreased amount, abnormal
Long-pec pericardium edematous, abnormal
Long-pec trunk curved ventral, abnormal
WT + MO1-sap130a + MO1-sap130b standard conditions Long-pec extension absent, abnormal
Long-pec floor plate absent, abnormal
Long-pec head morphology, abnormal
Long-pec larval locomotory behavior process quality, abnormal
Long-pec thigmotaxis process quality, abnormal
Long-pec trunk curved ventral, abnormal
Long-pec trunk increased thickness, abnormal
Day 5 hatching disrupted, abnormal
WT + MO1-scgn standard conditions Long-pec brain decreased size, abnormal
Long-pec brain edematous, abnormal
Long-pec head decreased size, abnormal
Long-pec pericardium edematous, abnormal
Long-pec whole organism anatomical axis decreased length, abnormal
Day 5 brain decreased size, abnormal
Day 5 whole organism anatomical axis length, normal
WT + MO1-thnsl2 standard conditions Long-pec brain decreased size, abnormal
Long-pec brain edematous, abnormal
Long-pec eye decreased size, abnormal
Long-pec head decreased size, abnormal
Long-pec heart morphology, abnormal
Long-pec larval locomotory behavior process quality, abnormal
Long-pec pericardium edematous, abnormal
WT + MO1-wwc1 standard conditions Long-pec otic vesicle malformed, abnormal
Long-pec otolith decreased amount, abnormal
Protruding-mouth larval locomotory behavior process quality, abnormal
Day 5 head malformed, abnormal
Day 5 larval locomotory behavior process quality, normal
Day 5 otolith decreased amount, abnormal
WT + MO2-chd3 standard conditions Long-pec brain edematous, abnormal
Long-pec central nervous system decreased thickness, abnormal
Long-pec embryo development delayed, abnormal
Long-pec head morphology, abnormal
Long-pec heart morphology, abnormal
Long-pec whole organism decreased size, abnormal
WT + MO2-setd5 standard conditions Long-pec head decreased size, abnormal
Long-pec heart morphology, abnormal
Long-pec larval locomotory behavior process quality, abnormal
Long-pec pericardium edematous, abnormal
Protruding-mouth head decreased size, abnormal
Protruding-mouth heart morphology, abnormal
Protruding-mouth larval locomotory behavior process quality, abnormal
Protruding-mouth pericardium edematous, abnormal
WT + MO2-zranb1a + MO2-zranb1b standard conditions Long-pec brain decreased size, abnormal
Long-pec brain edematous, abnormal
Long-pec head decreased size, abnormal
Long-pec head malformed, abnormal
Protruding-mouth pericardium edematous, abnormal
Protruding-mouth trunk curved ventral, abnormal
Day 4 whole organism decreased size, abnormal
Day 5 head malformed, abnormal
WT + MO3-smarcd1 standard conditions Long-pec brain morphology, abnormal
Long-pec eye decreased size, abnormal
Long-pec head decreased size, abnormal
Long-pec heart morphology, abnormal
Long-pec melanocyte decreased amount, abnormal
Long-pec somite morphology, abnormal
Long-pec spinal cord decreased size, abnormal
Long-pec spinal cord decreased thickness, abnormal
Long-pec trunk curved ventral, abnormal
Long-pec whole organism apoptotic, abnormal
Long-pec whole organism decreased size, abnormal
Full text @ Nature