FIGURE

Fig. 5

ID

ZDB-FIG-150804-20

Publication

Strate et al., 2015 - Glypican4 promotes cardiac specification and differentiation by attenuating canonical Wnt and Bmp signaling

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Fig. 5

Blocking Bmp signaling in kny/gpc4 mutants restores cardiomyocyte differentiation. (A) Tg(hsp70:noggin3) embryos were heat-shocked at 16hpf and analyzed at 48hpf. (B) Reconstruction of confocal images of WT, kny/gpc4 mutant and kny/gpc4 mutant with Tg(hsp70:noggin3), heat-shocked at 16hpf. Embryos were stained for myl7:dsRed (false-colored in green) and Amhc (red). (C) Quantification of cardiomyocytes in ventricle and atrium of embryos shown in B (n=3 for each group). (D) Quantifications of nkx2.5⁺ and myl7⁺ cells in the ventricles of wild-type siblings, kny/gpc4 mutants and kny/gpc4 mutants after Noggin3 induction. (E) Ratio of nkx2.5⁺/myl7⁺ ventricular cells in wild-type siblings, kny/gpc4 mutants and kny/gpc4 mutants after Noggin3 induction. Results are represented as mean±s.e.m. *Pd0.05, **Pd0.01 (paired t-test).

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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