ZFIN ID: ZDB-FIG-150610-20
Ogino et al., 2015 - RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels. Proceedings of the National Academy of Sciences of the United States of America   112(9):2859-64 Full text @ Proc. Natl. Acad. Sci. USA
ADDITIONAL FIGURES
EXPRESSION / LABELING:
Antibodies:
Fish:
Anatomical Terms:
Stage: Long-pec
PHENOTYPE:
Fish:
Observed In:
Stage: Long-pec

Fig. 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details No data available
Antibody Labeling Details
Antibody Assay Fish Conditions Stage Qualifier Anatomy
Ab1-elavl IHC WT control Long-pec Rohon-Beard neuron
IHC rnf121tm342/tm342 standard conditions Long-pec Rohon-Beard neuron
Ab1-nfasc IHC WT control Long-pec Rohon-Beard neuron axon initial segment
IHC rnf121tm342/tm342 standard conditions Long-pec Rohon-Beard neuron axon initial segment
Ab2-scn IHC WT control Long-pec Rohon-Beard neuron axon initial segment
IHC Long-pec Rohon-Beard neuron cis-Golgi network
IHC Long-pec Rohon-Beard neuron endoplasmic reticulum
IHC Long-pec Rohon-Beard neuron neuron projection
IHC rnf121tm342/tm342 standard conditions Long-pec Not Detected Rohon-Beard neuron axon initial segment
IHC Long-pec Rohon-Beard neuron cis-Golgi network
IHC Long-pec Rohon-Beard neuron endoplasmic reticulum
Ab3-hspa5 IHC WT control Long-pec Rohon-Beard neuron cis-Golgi network
IHC Long-pec Rohon-Beard neuron endoplasmic reticulum
IHC rnf121tm342/tm342 standard conditions Long-pec Rohon-Beard neuron cis-Golgi network
IHC Long-pec Rohon-Beard neuron endoplasmic reticulum
Phenotype Details
Fish Conditions Stage Phenotype
rnf121tm342/tm342 standard conditions Long-pec Golgi to plasma membrane protein transport disrupted, abnormal
Long-pec motor neuron action potential, abnormal
Long-pec Rohon-Beard neuron action potential, abnormal
Long-pec Rohon-Beard neuron voltage-gated sodium channel complex accumulation Rohon-Beard neuron endoplasmic reticulum, abnormal
Long-pec Rohon-Beard neuron voltage-gated sodium channel complex accumulation Rohon-Beard neuron Golgi apparatus, abnormal
Long-pec skeletal muscle action potential, abnormal
Long-pec voltage-gated potassium channel activity process quality, normal
Long-pec voltage-gated sodium channel activity decreased process quality, abnormal
Full text @ Proc. Natl. Acad. Sci. USA