ZFIN ID: ZDB-FIG-150209-6
Wang et al., 2014 - Endoplasmic Reticulum Resident Protein 44 (ERp44) Deficiency in Mice and Zebrafish Leads to Cardiac Developmental and Functional Defects. Journal of the American Heart Association   3(5):12256-64 Full text @ J. Am. Heart Assoc.
Anatomical Term:
Stage Range: 1-cell to Days 45-89
Knockdown Reagents:
Observed In:
Stage Range: Prim-5 to Days 7-13

Fig. 9 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
erp44 Ab1-erp44 WT standard conditions 1-cell whole organism WB
1-cell whole organism RTPCR
64-cell whole organism RTPCR
Sphere whole organism RTPCR
75%-epiboly whole organism RTPCR
Prim-5 whole organism RTPCR
Ab1-erp44 Prim-5 whole organism WB
Ab1-erp44 Protruding-mouth whole organism WB
Protruding-mouth whole organism RTPCR
Ab1-erp44 Days 7-13 whole organism WB
Ab1-erp44 Days 14-20 whole organism WB
Days 14-20 whole organism RTPCR
Ab1-erp44 Days 30-44 whole organism WB
Days 45-89 whole organism RTPCR
Ab1-erp44 Days 45-89 whole organism WB
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
WT + MO1-erp44 standard conditions Prim-5 trunk curved, abnormal
Long-pec trunk curved, abnormal
Day 4 atrium morphology, abnormal
Day 4 cardiac ventricle morphology, abnormal
Day 4 endocardial cushion lacks parts or has fewer parts of type cardiac muscle cell, abnormal
Day 4 trunk curved, abnormal
Days 7-13 heart increased size, abnormal
WT + MO2-erp44 standard conditions Prim-5 - Protruding-mouth whole organism dead, abnormal
twu34Tg + MO1-erp44 standard conditions Long-pec atrium increased size, abnormal
Long-pec blood circulation decreased speed, abnormal
Long-pec heart looping disrupted, abnormal
Long-pec pericardium edematous, abnormal
Day 4 atrium increased size, abnormal
Day 4 blood circulation decreased speed, abnormal
Day 4 heart calcium-mediated signaling disrupted, abnormal
Day 4 heart looping disrupted, abnormal
Day 4 pericardium edematous, abnormal
Full text @ J. Am. Heart Assoc.