FIGURE

Fig. S10

ID

ZDB-FIG-150116-16

Publication

Maeda et al., 2014 - Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2

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Fig. S10

Decreased mechanosensitive responses of hair cells stably expressing Tmc2a^1–260-GFP-CAAX at 3 dpf. (A–A′′) Example of expression of the 260-aa N-terminal fragment in lateral-line hair cells. The bright oval-shaped puncta of exogenous Tmc2a fragments are enriched in apical hair bundles at the center of the rosette, although more label is present in the soma in comparison with the 117-aa fragment (Fig. S9). (Scale bar: 5 μm.) (B–D) Calcium transients in lateralline hair cells in response to 0.1-, 0.5-, and 1.0-s deflections. (E) Summary of responses normalized to transgenic R-GECO1 control hair cells.

Expression Data

Gene:	GFP
Fish:	vo10Tg; vo11Tg
Anatomical Term:	neuromast hair cell
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	vo10Tg; vo11Tg
Observed In:	neuromast hair cell detection of mechanical stimulus involved in sensory perception of sound
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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