FIGURE

Fig. 5

ID

ZDB-FIG-141216-5

Publication

Paardekooper Overman et al., 2014 - Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome

Other Figures

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Fig. 5

Partial knockdown of Fer cooperated with suboptimal expression of NS- and LS- but not WT Shp2 to induce developmental defects. A. Embryos were injected with control MO, Fer e9i9 MO and NS, LS or WT Shp2 mRNA as indicated, and imaged at 4 dpf. B. Alcian blue staining showing craniofacial defects scored on severity (green: wild type, yellow: mild phenotype, orange: moderate phenotype, red: severe phenotype). C. Embryos were scored based on craniofacial defect upon alcian blue staining. The number of embryos per condition is indicated. D. The angle of the ceratohyal was quantified as a measure of craniofacial defects (* p<0.005, Student′s t-test).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO2-fer
Knockdown Reagent:	MO2-fer
Observed In:	ceratohyal cartilage cranium
Stage:	Day 4

Phenotype Detail

Acknowledgments

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